Potentiated by quinlolones, macrolides, cimetidine, allopurinol, alcohol, estrogen oral contraceptives

Tacrine, inteferon alpha, disulphiram, fluvoxamine, verapramil, mexiletine,

Nizatidine, propranolol, methotrexate, pentoxyfiyline, ticlopodine, propafenone, thibendazole

Avoid betablockers, Diltiazem, fluconazole, ketoconazole, influenza vaccine,

Antagonised bty phenytoin, rifampicin, barbiturates, carbamazepine, primidone, rotonavir,

Sucralfate, isoproterenol, sulphinpyrazole,

Antagonize lithium, benzodiazepines, pancuronium, adenosine,

Seizures with ketamine.

Toxicity with sympathomimetics, St Johns wort, beta-agonists, diuretics, doxapram, corticosteroids,

Smokers have increased metabolism,

Bronchial asthma, pulmonary disease with spastic bronchial component

 Nausea, vomiting, epigastric pain, hematemesis,
diarrhea, head ache, insominia,

convulsions, palpitations, flushing,
CNS stimulation, diuresis, hypotension,

extrasystoles, life threatening arrhythmias,
tachypnoea,albuminuria, hyperglycaemia

Active peptic ulcer
Arrhythmias
Porohyria
Seizure disorders
Not for primary treatment of acute attacks
Concomittant use of ephidrine in children


Special precaution-
Cirrhosis,
CCF, pulmonary odema, Cardiac or liver disease. elderly
Fever, sepsis, shock.
Monitor serum levels, do not try to maintain non-tolerated dose.
Cor pulmonale.
Hyperthyroidism. Rapid metaboilizers.
Hypertension. Acute febril illness.
Chronic alcoholism.
Pregnancy
Lactation - not recommended

Bronchial asthma, pulmonary  disease with spastic bronchial component

Injection-
2-4 ml upto 2-3 times daily i.v. ( 2ml in 1 min ) i.m. & s.c.
Also as a combined inj with dextrose

Tablets
1-3 tabs thrice daily after food.

Syrup-
5-10ml 3 times daily

Retard tabs
150mg - 1 tab 2-3 times daily
300mg - 300mg 12 hourly. increase or reduce by 150mg increments if reqd.

To be taken after food

Contradicated for use during pregnancy

Lactation- not recommended