Angiography /Angioscopy

Most common adverse reaction is nausea

Headache. GI  distress, syncope, vomiting, hypotension, and other symptoms of hypersensitivity

Cardiac arrest, severe shock, convulsions, thrombophlebitis at the site of injection and rare
cases of death have been reported

Generalized hives and itching , bronchospasm, and anaphylaxis, have been reported

A strong taste  may develop at thev site of injection

Hypersensitivity to any component of the component.

Special precaution/Warnings-

Extravasation- care must be taken to avoid extravasation during injectionbecause of the
high pH of fluorescein solution can result in severe local tissue damage

Special risk patients - excercise caution in patients with a history of allergy or bronchial
asthma. . An emergenct tray including 0.1% ephnephrine for IM or Iv use , an antihistamine
soluble steroid and aminophylline fo IV use and oxygen must always be available in case
 of an emergency

Pregnancy- avoid angiography on patients who are pregnant, especialy those in the first
trimester.

Lactation-excecise caution when  fluoresin is administered to a nursing woman.

Children- safety and efficacy in children have not been established

Indication-

Angiography /Angioscopy

Dosage-
Inject contents of the ampule/vial rapidly into the antecubical vein after taking precautions
to avoid extravasation

For children  the dose is calculated on the basis of 35mg in 10 pounds of body weight.

Store - at 15C to 25C ( 59 to 77 F ). Protect from freezing.

Skin will attain a temporory yellowish discoloration.
Urine attains a bright yellow color

Discoloration of the skin fades in 6 to 12 hours hours, urine fluorescence in 24 to 36 hours

Pregnancy-
Avoid angiography on patients who are pregnant, especialy those in the first
trimester.

Lactation-
Excecise caution when  fluoresin is administered to a nursing woman.

Children-
Safety and efficacy in children have not been established