Indication:
GI adrenocarcenoma metastatic to the liver
Adverse Reaction:
Most common adverse reaction-
diarrhea, enteritis, localized erythema, nausea, stomatitis and vomiting.
Cardiovascular - Myocardial ischema
CNS - lerthargy, malaise, weakness
Dermatologic - alopecia, dermatitis, nonspecific skin toxicity, rash
GI - abnormal pain, acalcuous cholecytitis, anorexia, bleeding, cramps, duodenal ulcer,
duodenitis, gastritis, gastroenteritis,glossitis, pharyngitis, and possible intra- and
extrahepatic biliary sclerosis
Lab test abnormalites- bromosulphthalein, prothrombin, sedmentation rate, thrombopenia, total proteins
Local - abscees, arterial aneurysm, arterial ischemia, bleeding at catheter site, cather blocked, displaced or leaking
Contra-Indications:
Poor nutritional state, depressed bone marrow function, potentially serioous infections.
Special Precautions/Warnings-
First course of therapy- due to possibliy of severe toxic reactions, hospitalize all patients
for the first course of therapy
Combination therapy - any form of therapy that adds stress to the patient, interferes with nutriotion or depress bone marrow will increase the toxicity to floxurdine
Renal function impairment - use floxurdine with extreme caution in patients with impaired hepatic or renal function.
Special risk - use floxurdine with extreme caution in poor risk patients with a history of high
dose pelvic irradiation or previous use of alkylating agents
Discontinuation of therapy- therapy to be discontinued when first signs of toxicity appears
Myocardial ischema,
Stomatis or esophagopharyngitis
Leukopenia WBC count under 3500 or rapidly falling blood count
Vomiting
Diarrhea, frequent bowel movement
GIulceration
Thrombocytopenia
Pregnancy- advice women of child bearing age to avoid becoming pregnant
Lactation- advice mothers not to breast feed while receiving the drug
Children- safety and efficacy in children has not been established
Monitoring - careful monitoring of WBC and platelet count is recommended
Haemorrhage from any site
Dosages/ Overdosage Etc:
Indication-
GI adrenocarcenoma metastatic to the liver
Dosage-
the recommended therapeutic dose scheduleof floxrudine by continous arterial infusion is
0.1 to 0.6mg/kg/day .
Higher dose ranges from 0.4 to 0.6mg/kg/day are usually employed for hepatic artery infusion
because the liver metabolizes the drug, thus reducing the potential for systemic toxicity.
Reconstituton- each vial must be reconstituted with 5ml of sterile water for injection to yield
a solution containing approx 100mg/ml of floxurdine
Patient Information:
Ref - USP PDI Vol II 17th Edition (1997)
1.Allergies-
Tell your doctor if you have ever had any unusual or allergic reaction to
floxuridine.
2.Pregnancy-
There is a chance that this medicine may cause birth defects if either the male
or the female is receiving it at the time of conception, or during pregnancy.
Tell your doctor right away if you think that you have become pregnant while
receiving floxuridine
3. Breast-feeding-
Tell your doctor if you are breast feeding or if you intend to breast feed during
treatment. because floxuridine may cause serious side effects, breast-feeding
is not recommended while receiving it
4.Children-
There is no specific information comparing the use of floxuridine in children
with use in other age groups.
5.Older adults-
Although there is no specific information comparing use of floxuridine in the
elderly with use in other age groups, this medicine is not expected to cause
different side effects in older people than it does in younger adults.
6. Other medicines-
When you are receiving floxuridine it is sepecially important that doctor
know if you are taking any of the following-
Amphotericin B
Antithyroid agents
Azathioprine
Chloramphenicol
Flucytosine
Ganciclovir
Plicamycin
Ziduvudine or
If you have been treated with radiation or cancer medicines,- floxuridine
may increase the effects of any of these medicines
7. Other medical problems-
The presence of other medical problems may affect the use of floxuridine.
Make sure you tell your doctor if you have any other medical problems
especially-
Chickenpox or exosure to
Herpes zoster - risk of severe disease affecting other parts of your body
Hepatitis - history of
Kidney disease
Liver disease -effects of folxuridine may be increased because of slower
removal from the body
Infection- flouridine can decrease your bodys ability to fight infection
.
.
Pregnancy and lactation:
Pregnancy-
Advice women of child bearing age to avoid becoming pregnant
Lactation-
Advice mothers not to breast feed while receiving the drug
Children-
Safety and efficacy in children has not been established
Manufacturer Details