Drug Interaction:
Drug interactions- summary
Androgens/estrogens/ progestins/or glucocorticoids-
gonadorelin test should be conducted in the absence of other drugs that directly affect
the pitutiary secretion of the gonadorelin.
Levodopa/and spironolactone -
gonadorolein levels may be elevated by spironolactone and minimally by levodopa
Digoxin/and oral contraceptives -
gonadrorelin levels may be suppressed by oral contraceptives and digoxin
Phenothiazine and dopamine antagonists-
response of gonadorolin may be blunted by phenothiazine and dopamine antagonists
which cause rise in prolactin.
Indication:
Gonadorelin test
Adverse Reaction:
Cardiovascular - flushing
CNS - headache, lightheadeness
Dermatologic- local swelling, pain and puritus at injection site, local skin rash after
chronic subcutaneous administration
GI - nause, abdominal discomfort
Hypersensitivity - rare bronchospasms, tachycardia, flushing, urticaria, induration at
injection site, anaphylactic reactions
Miscellaneous - pitutitary apoplexy and sudden blindness following gonadrotropin
releasing hormone administration to a patient with a gonadrotropin-
secreting adenoma
Contra-Indications:
Hypersensitivity to gondorelin or any of its components
Special Precautions/Warnings-
Antibody formation- antibody formation reported after chronic administration of large
doses of gonadorelin hydrochloride
Hypersensitivity - no reactions have been reported following a single 100mcg dose of
gonadorelin hydrochloride. Rarely reported with multi doses of gomadrolien hydrochloride
Pregnancy - drug should be used during pregnancy only if needed.
Lactation- caution should be excercised when gonadorelin hydrochloride to breast feeding
woman.
Children- safety and effectiveness in pediastric patients have not been established
Dosages/ Overdosage Etc:
Indication-
Gonadorelin test
Dosage-
Adults - 100mg mcg dose subcutaneously or intravenously. In female for whom the phase
of the menstrual cycle can be established the test should be performed in the early folicular
phase days ( days 1 to 7)
Storage- store at room temperature approx 77F .After reconstitution store at room temperature and use within 1 day. Discard unsed solution and diluent.
Patient Information:
Ref - USP PDI Vol II 17th Edition (1997)
1.Allergies-
Tell your doctor if you are have ever had any unusual or allergic reaction to
gonadorelin. Also tell your healthcare care professional if you are allergic to
any other substances such as foods. preservatives or dyes.
2.Pregnancy-
Studies have not been done in humans. However, gonadorelin has not shown
to cause birth defects or other problems in animal studies.
3. Breast-feeding-
Mothers who are taking this medicine and who wish to breast feed should
discuss this with their doctor.
4.Children-
In effective doses the medicine has not been shown to cause different side effects or
problems than it does in adults.
5. Other medicines-
Tell your doctor if you are using any other prescription or non-prescription
(Over-the counter) OTC medicine.
Pregnancy and lactation:
Pregnancy -
Drug should be used during pregnancy only if needed.
Lactation- Caution should be excercised when gonadorelin hydrochloride to breast feeding
woman.
Children-
Safety and effectiveness in pediatric patients have not been established
Manufacturer Details