Drug interactions -summary-

+ Coccidiodin

Immunosuppressants-

reactivity to delayed hypersensitivity test may be suppressed in persons receiving
corticosteroids or immunosuppressive drugs or in persons recently immunized with
live vaccines eg measles, mumps , ribella, poliovirus
If delayed hypersenstivity is indicated perform it either preceding or simultaneous
with immunization  or 4 to 6 weeks after immunization

Cimetidine -

cimetidine therapy may augument or enhance delayed hypersensitivity response
to skin test antigens. The affect may be mediated through cimetidine binding
suppressors T-lymphocytes

Coccidiomycosis diagnosis

Local -  occasional patient may develop wheal reaction. Occasionally local reaction
may lead to vesiculation , local tissue necrosis and  scar formation

Systemic - rarely develop great sensitivity reactions consisting of fever or erythema
nodusum.

Hypersensitivity  to thimerosal

Special Precautions/ Warnings-

Immunodeficiency - persons receiving immunosuppressive therapy or with other
immunodeficiencies may have a diminished skin-test response

Indication-

Coccidiomycosis diagnosis

Dosage -
inject 0.1ml of a 1:100 duilution intradermally on the flexor surface of the forearm.
Use  waeaker 1:1000 or  1: 10,000  dilution if erythema nodosum is evident  

Storage- Store at 2 to 8C ( 36 to 46F ) Discard if frozen. Product tolerate 14 days at
room temperature. Refrigerate dilutions and discard within 24 hours.