For external use only. Avoid contact with the eyes.

Hypersensitivity- 
No allergic sensitivity or toxic reactions have been noted in clinical use when used
as directed

However, a case of systemic manifestation of hypersensitivity to collagenase in a patient
treated for more than 1 year with a combination of collagenase and cortisone has been
reported

Local or systemic hypersensitivity to collagenase

Special Precautions/Warnings-
For external use only. Avoid contact with the eyes.

Cleansing materials  such as hydrogen peroxide , Dakins solution and normal saline was not confined to the wound. Therefore apply the ointment carefully within the area of the wound.

Eryhthema - a slight transcient erythema has been noted ocassionally in the surrounding
tissue, particularly when collgenase ointment was not confined to the wound. Therefore,
apply the ointment carefully within the area of the wound.

Children- safety and efficacy in pediatric patients have not been established

Pregnancy- no information available regarding collagenase on pregnant women.

Lactation- no information regarding collagenase in breast feeding woman.

Monitoring- monitor debilated patients closely for systemic bacterial infections because
the theoretical possibilty that debriding enzymes may increase the risk of bacteremia

Indication-

Dermal ulcer

Dosage-
Collagenase ointment should be applied once daily( or more frequently if the dressing becomes soiled as from inconitinence)

1. For external use only. Avoid contact with the eyes.

Children-
Safety and efficacy in pediatric patients have not been established

Pregnancy-
No information available regarding collagenase on pregnant women.

Lactation-
No information regarding collagenase in breast feeding woman.