APTIVUS*


Brand:
APTIVUS*

Manufacturer:
BOEHRINGER-INGELHEIM INC

  
Compositions:
Tipranavir 250mg capsules,
  
Strength Rate Packing Style
250mg 0.00 120s capsules

List of Related Indications:
  • HIV infection

List Of Drugs:
  • Tipranavir - Anti- Viral agents

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pregnancy and lactation

   

Drug Interaction:

Drug Interactions -summary-

+ Tipanavir

Aluminium and magnesium based antacids-
aluminium and magnesium antacids may decrease tipranavir absorption .
consider separating tipranavir. ritonavir dosing from antacid administration

Azole antifungals ( fluconazole ) + tipranazole / tipranavir + azole antifungals ( fluconazole,
 ketoconazole,voriconazole )

fluconazole may increase tipranazole concentrations. Dosage adjustments is not needed
High dose( > 200mg) of fluconazole, itraconazole and ketoconazole are not recommended

Clarithromycin+ Tipranavir /Tipranavir + clarithromycin
concurrent use may increase tipranavir and clarithromycin levels. Dosage adjustments
are not recommended in patients with healthy renal function

Efranavir
efranavir coadministered with tipranavir/ritonavir ( 500mg/100mg twice daily) may cause
tiprnavir concentrations to decrease


Loperamide+ tipranavir/Tipranavir + loperamide -
coadmin my decrease the concentration of both tipranavir and loperamide

Rifamycin ( rifampin ) + tipranavir/ Tipranavir + rifamycin-
coadmin of tipranavir with rifampin may lead to loss of virologic response and possible
resistence to tipranavir

St Johns wart-
coadmin may lead to loss of virologic response and posible resistence to tipranavir.
Cuncurrent use is not recommended

Tenovir + tiprnavir/Tipranavir+ tenovir-
coadmin may decrease concentrations of both tiprnavir and tenovir

Antihistamines -
coadministration  is contraindicated because of life threatening cardiac arrhythmias

Antiarrhythmics agents - (amidarone,bepiridil, flecanide, propafenone, quinidine )
coadmin is contraindicated because of life threatening cardiac arrhythmias
 
Benzodiapines ( midazolam, triazolam ) -

coadmin is contraindicated because of risk of prolonged increased sedation or
respiratory depression