Drug interactions- summary-

Cevimeline +

Betablockers -                                                                                                                                     administer with caution to patients taking betablockers because of possibilty
of conduction disturbances

Parasympathomimetics-
drugs with parasympathometic effects administered concurrently with cevimeline
 may have additive effects

Antimuscarinics-
cevimeline interfere with desirable antimuscararinic effects of drugs used concomittantly

Dry mouth

Adverse reactions-

Headache  14%     sinusitis  12%             uper respiratory tract infection  10%

Dyspepsia 7%      abdominal pain  7%  urinary tract infection  6%

Coughing   6%       pharynigitis    5%       vomiting   4%        injury   4%

Back pain  4%      rash    4%                      conjuntivitis 4%     dizziness 4%

Bronchitis  4%     Arthalgia  3%                 fatigue   3%           pain  3%

Insomnia   2%     hot flushes 2%              rigors   1%              anxiety 1%

Uncontrolled asthma, hypersensitivity to the drug

Special Precautions-

Cardiovascular disease - Cevimeline to be used with caution and under close medical
supervision in patients with a history of cardiovascular  disease eg angina pectoris
or myocardial infaction

Pulmonary disease- to be usd with caution in patients with controlled asthma, chronic bronchitis,
or chronic obstructive disease

Ocular - Cevimeline  may cause visual disturbances especially at night.
Caution to be excercised while driving or performing hazardous tasks

Toxicity - cevimeline toxicity is characterised by headache, visual  disturbances , lacrimation,
 rspiratory distress,sweating, GI spasm

Hazardous tasks- caution to be excercised while driving at night or performing hazardous
tasks in reduced lighting

Pregnancy-  cevimeline should be used during pregnancy only if the potential benefit
justifies the potential risk to the fetus.

Lactation- decide whether to discontinue nursing or the drug depending on the importance
of the drug to the mother

Children- safety and efficacy in children has not been established

Elderly- special care to be excercised when cevimeline is used in elderly taking
into consideration greater  frequency of decreased hepatic, renal or cardiac function
and of concomitant disease or use of other drugs.

Indication-
Dry mouth

Dosage-30mg 3 times a day.
Not enough data available to support doses greater 30mg 3 times a day.

1. Patients should be informed that cevimeline may cause visual  disturbances, especially
   at night and that coould impair their ability to drive

2. If patients sweat excessively  while taking cevimiline dehydration may develop.
    patients should drink extra water and consult their doctor

Pregnancy- 
Cevimeline should be used during pregnancy only if the potential benefit
justifies the potential risk to the fetus.

Lactation-
Decide whether to discontinue nursing or the drug depending on the importance
of the drug to the mother

Children-
Safety and efficacy in children has not been established

Elderly-
Special care to be excercised when cevimeline is used in elderly taking
into consideration greater  frequency of decreased hepatic, renal or cardiac function
and of concomitant disease or use of other drugs.