Drug interactions- summary

Betablockers eg propranolol ,, corticosteroids, doxycycline, estrogens, ( including oral
contraceptives ), felodipine, griseofluvin, nifedipine, phenylbutazone, quinidine,
theophylline , warfarin -
effects of drugs may be decreased

Carbamazepine, sulfinpyrazone-
may increase risk of hepatoxicity

MAOIs inhibitors-
may increase CNS effects

Other CNS depressants( ethanol, narcotics, gneral anesthetics, traquilizers , sedative -
hypnotics)-
CNS effects may occur

Tricyclic antidepressants-
antidepressant effect may decrease

Drug lab test interactions-
with home blood glucose systems, may cause decrease in mean glucose values,
may give false urinary 5-hydroxyindoleacetic acid result.

Tension or muscle contraction headache

CNS - drowsiness, dizziness, lightheadedness, confusion

Dermatologic-   rash

GI -  nausea, vomying, flatulence

Special precautions-
Drug dependency-  prolonged use may produce drug ,tolerance depnency (, physiological and
 physical )

Pregnancy - observe caution

Lactation- undetermined

Children - safety and efficacy in children under 12 years not established

Indication-
Tension or muscle contraction headache

Dosage-
Adults  1 to 2 tablets or capsules every 4 hours
Maximum - 6 tablets  or caosules /day

Children-
12 years of age and older-
see adult dosing

1. Caution patients that dependency .tolerance may result from long term use.

2. Tell patients to take food with food or full glass of water

3. Instruct patients not to discontinue after long-term regular use.

4. Caution patients to avoid intake of alcoholic beverages and other CNS with depressants
    without the the approval of their doctor.

5. Warn patients to avoid any hazardous activity (eg driving, smoking ) if dizziness, drowsiness,
   or decrease in mental  acuity occurs.

6. Warn patients that orthostatic hypotension may occur. Instruct patients to change positions
    slowly and to sit or lie down if symptoms occur 

7. Instruct patients not to take OTC medicines without consulting their doctor.

8. Advice patients to report any of the following symptoms to their doctor, eg, persistent or
    recurrent pain before next schedule dose, difficulty in breathing, increased drowsiness,
   vomiting or yellowing of skin or gums. 
    increased drowsiness, vomiting, abdominal pain , tarry stools ,inusual bruising or bleeding.

To be taken with food or full glass of water
 

Pregnancy -
Observe caution

Lactation-
Undetermined

Children -
Safety and efficacy in children under 12 years not established