Adverse Reaction:
Adverse reactions-
Cardiovascular - orthostatic dizziness and syncope . postural hypotension
CNS - convulsions , choreform movements, mental abberations, tremor, and paresthesis
GI- ileus, constipation ( some times preceded by small .frequent liquid stools)
vomiting, nausea, anorexia, glossitis, and dryness of mouth
GU- urinary retention, impotence, decreased libido,
Respiratory- intestinal pulmonary edema, and fibrosis
Special senses- blurred vision, dilated puplis
Miscellaneous - weakness, fatigue, sedation
Contra-Indications:
Special precautions-
Mecamylamine should not be used in mild , moderate, labile hypertension and may unsuitable
in uncooperative patients.
It is contraindicated in coronary insufficiency or recent myocardial infarction
Renal insufficiency- mecamylamine should be given with great discretion if at all when renal
insufficiency is manifested by a rising or elevated BUN .
The drug is contraindicated in uremia
Other contraindications are glaucoma, organic pyloric stenosis or hypersensitivity to the product
CNS effects- readily penetrates into the brain and produce CNS effects.
Tremor, cholreiform movements may occur rarely
Dicontinuation of therapy- the effects of mecamylamine may last hours to days after therapy
is discontinued
Renal function impairment- evaluate patients condition particularly renal and cardovascular
function. Give with great discretion
Special risk- frequent bowel movements with abdominal distention and decreased borborygmi
may be first sign of paralytic ileus. If these are present discontinue the drug
Pregnancy- administer to a pregnant women only if clearly needed.
Lactation- decide whether to discontinue breast feeding or the drug depending on the
importance of drug to the mother.
Children- safety and and efficacy have not been established
Patient Information:
1. Take after meals. Use consistent timings in relation to meals
2. Mecamylamine may cause dizziness, light-headeness or fainting especially when rising from lying or sitting position.
3. This effect may be inceased by alchololic beverages, excercise or during hot weather.
Getting up slowly may help alleviate such a reaction
Ref - USP PDI Vol II 17th Edition (1997)
1.Allergies-
Tell your doctor if you have ever had any unusual or allergic reaction to
Mecammylamine Also tell your healthcare care professional if you are allergic
to any other substances such as foods. preservatives or dyes.
2.Pregnancy-
Studies have not been done in humans or animals.However, use of Mecamylamine
during pregnancy is not recommended.
3. Breast-feeding-
It is known whether mecamylamine passes into breast milk. However, this medicine
has not been reported to cause problems in nursing babies.
4.Children-
Studies of this medicine has been done only in adult patients and there is no specific
information comparing use of mecamylamine in children with use in other age groups.
5.Older adults-
Dizziness or lightheadedness may be more likely to occur in the elderly, who are
more sensitive to the effects of mecamylamine.
6. Other medicines-
Tell your doctor if you are using any of the following -
Antibiotics or
Sulfonamides - patients with chronic pyelonenphritis being treated with
these medicines should not treated with mecamylamine
Antimyasthenics - eg ambenonium, neostigmine, pyridoxime,-
effects of these medicines may be decreased by mecamylamine
Urinary alkaliners- effects of mecamylamine may be increased
because these medicines cause it to be removed more slowly from
the body
7. Other medical problems-
Make sure you tell your doctor if you have any other medical problems
especially-
Bladder or prostrate problems - mecamylamine may interfere with
urination
Bowel problems- patients with bowel problems who take mecamylamine
may be at increased risk for serious bowel effects of mecamylamine
Diarrhea or
Fever or infection or
Nausea or vomiting - effects of mecalmylamine on blood pressure
may be increased
Glaucoma- mecamylamine may make the condition worse.
Heart or blood vessel disease or
Heart attack - lowering of blood pressure by mecalmylamine
may make problems resulting from these conditions worse.
Kidney disease- effects of mecaylamine may be increased because
of slower removal from the body.
Manufacturer Details