Risk of hypokalemia increased by co-admin of corticoseroids, diuretics or xanthine prolong action of drugs eg. suxamethonium

Fine tremor of skeletal muscles eg hands, palpitations, and muscle cramps, tachycardia, tenseness and peripheral vasodilation

severe hepatic impairment, cirrhosis

Special precautions-

Hyperthyroidism , myocarial insufficiency Arrhythmias, susceptibility to QT- interval prolongation Pregnancy

Indication-

Reversible airway obstruction

Dosage-

10-20mg once daily at bed time

Pharmacology:

Bambuterol is stable to presystemic elimination and is concentrated by lung tissue following its absorption from the GIT. Bambuterol is hydrolysed to terbutaline the active Beta adrenergic receptor agonist

Pharmacokinetics:

The mean peak terbutaline concentration at steady state occurs between 3.9 and 6.8 hours. Cmax is higher when the dose is ingested in the evening compared with the morning, but not age related.

Preferably taken shortly before bed time

Use contraindicated Observe caution.