Drug Interaction:
Drugs covered:
1st generation 2nd generation 3rd generation
. Cephalexin Cefaclor Cefixime
Cefadroxil Cefamandole Cefoperazone
Cephadrine Cefotoxitin Cefotaxime
Cephalothin Cefuroxime Ceftizoxime
Cephapirin Cefonicid Ceftriaxone
Cefazolin Cefmetazole Ceftazidime
Cefotetan Ceftibuten
Cefprozil Cefepime
Cefpodoxime
Loracarbef
Refer Cephalosporins
Concomittant administration of high doses of antacids like sodium bicarbonate or Aluminium hydroxide or H2 blocks, decreases the paek plasma levels by 24- 42% and the extent of absorption by 27- 32%.
Oral anticholinegics delay the attainment of peak plasma levels but not affect the extent of absorption. Renal excretion is inhibited by probenecid, resulting in increase in AUC and also peak Cefpodoxine levels
Indication:
Approved by FDA on August, 1992
U.S.FDA APPROVED DRUGS FROM 01-01-08 TO 31-12-08
Drug name Indication Date of Approval
66. Cefpodoxime 50mg 31-01-08
+ Clavulanic acid 31.25mg dispersible tablet
& dry syrup
(Addl.Stgth)
Same as approved
U.S FDA APPROVED DRUGS DURING 2007
116. Cefpodoxime (as Proxetil) 30-07-07
(100mg/200mg) +
Clavulanic acid 962.5/125mg) tablet
For LRTI,URTI, and UTI
Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
1. Cefpoxiime For bronchitis September 1997
Proxetil
2. Cefpoxime Proxetil 14-03-1996
Antibacterial for use in adult and children with mild to moderate
infections invloving ,URT, LRT skin and soft tissue,UTI ,
sexually transmitted infections
3.Cefpodoxime proxetil 30.07-2007
100mg/200mg + Clavulanic acid
62./125mg tablet
For LRTI,URTI,and UTI
4. Cefpodoxime 06-08-2010
100/200mg + Dicloxacin ER 500mg/500mg
For the treatment of Lower RI, Skin and Soft Tissue, Bone and
Joint Infections and ENT Infections in Adult patients prone to
antibiotic induced diarrhoea
5. Cefpodoxime 50mg + Clavulanic acid 31.01-2008
31.25mg Dispersible tablet & dry syrup
Addl.Strgth.
Same as approved
6. Cefpodoxime IP 16-04-2011
100mg/100mg/200mg/200mg + Ofloxacin
IP 100mg/200mg/100mg/200mg tablets
For thetreatment of Lower and Upper Respiratory tract
infection and Typhoid fever in adults only
FIXED DOSE COMBINATIONS APPROVED BY DCG(I)
FROM JANUARY 1961 TILL NOVEMBER 2014
Name of Drug Indication Date of Approval
1.Cefpoxime 100mg + 31-01-2008
Clavulanate Potassium 62.5mg Dispersible tablet/
Dry syrup
For LRTI, URTI, and UTI
2.Cefpodoxime 100mg + 29-11-2012
Ofloxacin 100mg dispersible tablet
Addl.Dosage Form
For the treatment of Lower and upper respiratory tract infection and
Typhoid fever in adults only
Drugs covered:
1st generation 2nd generation 3rd generation
. Cephalexin Cefaclor Cefixime
Cefadroxil Cefamandole Cefoperazone
Cephadrine Cefotoxitin Cefotaxime
Cephalothin Cefuroxime Ceftizoxime
Cephapirin Cefonicid Ceftriaxone
Cefazolin Cefmetazole Ceftazidime
Cefotetan Ceftibuten
Cefprozil Cefepime
Cefpodoxime
Loracarbef
Refer Cephalosporins
Dosages/ Overdosage Etc:
Approved by FDA on August, 1992
Indications: Lower respiratory tract infection
Dosage: Adults- total daily dose- 400mg given 200mg every 12 hours for 14 days
Children- Total daily dose - 10mg/kg/day given 10mg/kg/every 24 hours for10 days
Manufacturer Details