SANOFI INDIA LTD SANOFI HOUSE, CTS NO 117-B L&T BUSINESS PARK SAKI VIHAR ROAD, POWAI ANDHERI EAST, MUMBAI 400072
Clobazam 5mg/10mg tablets,
List of Related Indications:
List Of Drugs:
- Clobazam -Onfi -@- Benzodiaopines (Nov 1997)
Indication Type Description:
Dosages/ Overdosage Etc
Interaction with Food
Pregnancy and lactation
Alprozolam, Chlordiazepoxide, Clonazepam, Clorazepate,Diazepam, Halazepam, Lorazepam, Oxazepam, Prazazepam
Interacting drugs - summary
additive CNS depressant effects CNS depressants
Asthenia and symptoms of tiredness, especially at the start of treatment and with higher doses, may occur.
Others include dryness of mouth, constipation, anorexia, nausea, dizziness and fine tremors.
Restlessness, irritability, agitation, anxiety, suicidal tendencies, frequent muscle spasms.
Worsening of respiratory symptoms and respiratory depression can occur.
Hypersensitivity to other benzodiazepines
Myasthenia gravis, Severe respiratory insufficiency.
CAL with incipient respiratory failure Sleep apnea,
History of drug/ alcohol dependence,
Severe hepatic impairment
Pregnany and lactation not recommended.
Extreme caution is necessary if clobazam is required to be administered to patients with myasthenia gravis, spinal cerebellar ataxia, serious liver damage or sleep apnea syndrome. In patients with history of respiratory diseases.
Dosages/ Overdosage Etc:
Date of Approval 1997
Anxiety, tension and agitation
Adults 10 -30 mg Elderly- 10- 20 mg all daily in divided doses
Max daily- 60mg Lower the dose in renal/hepatic impairment
Not recommended for children below 3 years - 3-12 years - half the adult dose
Clobazam is structurally and pharmacologically related to approved benzodiazepines.
Oral clobazam is 87% absorbed. Concomittant administration with alcohol increases clobazam's bioavailabity by 50% Food may slow the rate, but not the total absorption.
The mean half-life of the unchanged drug is 18 hrs and upto 77 hrs for metabolites.
Clobozam is 81% to 97% excreted in the urine, accumulation is expected in impaired renal function.
Interaction with Food:
Food may slow rate,but does not alter the absorption.
Pregnancy and lactation:
Not recommended during first trimester of pregnancy & should be given in later stages only if there are compelling reasons
Clobazepam is excreted into breast milk and should not be used during lactation. If there are compelling reasons for its use, then nursing should be stopped.