Drug Interaction:
Protien bound levels may be increased during treatment and interfere with the results of thyroid function tests. These efffects may persist for as long as 6 months after discontinuation of therapy
Indication:
Treatment of intestinal amebiasis
Adverse Reaction:
Neurotoxicity,sub-acute optico-myleoneuropathy. Optic neuritis, atrophy and peripheral neuropathy (especially in children given high doses for a long time),
Dermatologic- various forms of skin eruptions ( acneform , papular, pastular, bullae, vegetating or tuberous ioderma ) uticaria, pruritus
GI -abdominal cramps, nausea and diarrhoea, pruritis ani, skin eruptions enlargement of thyroid (due to iodine content). Fever, chills, headache and vertigo.
Topical application: Contact allergy, irritant dermatitis
Contra-Indications:
Hypersensitive to any 8-hydroxyquinoline eg. iodoquinol , iodohydroxyquin or iodine containing preparations, epatic damage
Warning
optic neuritis , optic atropthy and peripheral neuropathy have occured following prolonged high dosage therapy, avoid long term therapy
Special precautions: Renal dysfunction,thyroid disease and neurological disorders. Pregnancy- Safety for use during pregnancy and in nursing mother has not been established
Dosages/ Overdosage Etc:
Indications: Intestinal amebiasis.
Dosage: 650mg 3 times daily after meals for 20 days.
Children - 40mg/kg daily(maximum 650mg/dose) in 3 divided for 20 days..
Patient Information:
Ref - USP PDI Vol II 17th Edition (1997)
1.Allergies-
Tell your doctor if you have ever had any unusual or allergic reaction to
Iodoquinol , chloroxine, cliquinol, iodine, pramaquine, pentaquine or primaquine.
Also tell your healthcare care professional if you are allergic to any other
substances such as foods. preservatives or dyes.
2.Pregnancy-
Iodoqionol has not been reported to cause birth defects or other problems
in humans.
3. Breast-feeding-
It is not known whether Iodoquinol passes into breast milk. Mothers who are
taking this medicine and who wish to breast feed should discuss this
with their doctor.
4.Children-
Children may be more likely to develop side effects especially it given high doses for
a long time.
5.Older adults-
There is no specific information comparing use of iodoquinol in the elderly with use
in other age groups
6. Other medicines-
Tell your doctor if you are using any ther prescription or non-prescription
(Over-the counter) OTC medicine.
7. Other medical problems-
The presence of other medical problems may affect the use of Iodoquinol.
Make sure you tell your doctor if you have any other medical problems
especially-
Eye disease- Iodoquinol may cause side effects affecting the eye or make
eye condition worse.
Kidney disease or
Liver disease or
Thyroid disease - patients having these diseases may have an increased chance
of side effects.
Pharmacology/ Pharmacokinetics:
Pharmacology:
Iodoquinol is effective against the trophozolites and cysts of Entomoeba histolytica in the large intestine. Because it is poorly absorbed in the GI tract, the drug can reach high concentrations in the intestinal lumen, and produces its potent amebicidal effect precisely at the site of infection, without any significant systemic absorption.
Interaction with Food:
None reported
Pregnancy and lactation:
Safety for use during pregnancy and in nursing mother has not been established
Manufacturer Details