Chloroquine- systemic
1. May cause GI upset: take with food. Complete full course of therapy
2. Report visual disturbances or difficulty in hearing or ringing in ears to physician
3. Keep out of reach of children: overdoses is especiallly dangerous to children.
4. Medication may cause diarrhea, loss of appetite, nausea, stomach pain, or vomitting, muscle
weakness or rash. Notify physician if pronounced or bothersome.
AVOID CONCURRENT USE WITH ERYTHROMYCIN
5.Allergies-
Tell your doctor if you are have ever had any unusual or allergic reaction to
chloroquine or hydrochloroquinone. Also tell your healthcare care professional
if you are allergic to any other substances such as foods. preservatives or dyes.
6.Pregnancy-
Unless you are taking it for malaria or liver disease caused by protozoa,
use of this medicine is not recommended during pregnancy, In animals,
chloroquine has been shown to cause damage to the central nervous system
(brain and and spinal cord) of the fetus, including damage to hearing, sense
of balance, bleeding in the eye and other problems.
However, when given in low doses ( once a week) to prevent malaria, this medicine
has not been shown to cause birth defects or problems in humans
7. Breast-feeding-
Chloroquine passes into breast milk.Chloroquine has not been reported to cause
problems in nursing babies to date.However, babies and children are especially
sensitive to the effects of chloroquine.
8.Children-
Children are especially sensitive to the effects of chloroquine. This may increase
the chance of side efffects during treatment. Overdose is especially dangerous
in children. Taking as little as one tablet (300mg -strngth) has resulted in the death
of a small child.
9.Older adults-
Many medicines have not been studied specifically in older people. Therefore,
it may not be known whether they work exactly the same way they do in
younger adults, or if they cause different side effects or problems in older people.
There is no specific information comparing use of chloroquine in the elderly with use
in other age groups
10. Other medicines-
Although certain medicines should not be used together at all, in other cases two
different medicines may be used together even if an interaction might occur.
In such cases your doctor may want to change the dose, or other precautions
may be necessary.
Tell your doctor if you are using any other prescription or non-prescription
(Over-the counter) OTC medicine.
12. Other medical problems-
The presence of other medical problems may affect the use of chloroquine.
Make sure you tell your doctor if you have any other medical problems
especially-
Blood diseases- (severe) -chloroquine may cause blood disorders
Eye or vision problems- chloroquine may cause serious side effects,
especially in high doses
Glucose- 6 -Phosphate dehydrogenase (G6PD) deficiency- chloroquine
may cause serious blood side effects in patients with this deficiency
Liver disease- may decrease the removal of chloroquine from the blood,
increasing the chance of side effects.
Nerve or brain disease( severe )- including convulsuons, (seizures) -
Chloroquine may cause muscle weakness and in high doses, seizures
Porphyria- chloroquine may cause episodes of prophyria to occur more
frequently
Stomach or intestinal disease (severe) - chloroquine may cause stomach
or intestinal irritation
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