Brand Information

Strength	Rate	Packing Style
80mg	42.20	10s tablets

Drug Interaction:

Sulfonylureas- include-

First generation - Acetohexamide, Chlorpropamide, Tolazamide, Tobutamide

Second generation - Glipizide, Glyburide ( Glibenclamide ), GlimepIride,Gliclazide

Refer Chlorpropamide

Interacting drugs - summary

+ Metformin

Alcohol

Alcohol potentiates the effect of metformin on lactate metabolism.

Warn patients against excessive alcohol intake, while receing metformin

Cationic drugs

Cationic drugs( eg amiloride, digoxin, morphine, procainamide,

quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin) eliminated by renal tubular secretion, have the potential for interaction with

metformin careful patient monitoring and dose adjustment of metformin recommended

Cimetidine

Cimetidine caused a 60% increase in peak metformin plasma and

whole blood concentrations and a 40% increase in plasma and

whole blood AUC

Furosemide + Metformin

Furosemide increased the metformin plasma and blood Cmax and

blood AUC , without any significant change in metformin renal clearance

Metformin +Furosemide

When administered with metformin, the Cmax and AUC of

furosemide were smaller than administered alone, and the terminal

half-life decreased, without any significant change in furosemide

renal clearance.

Iodinated contrast material

Parentral contrast studies with iodinated materials can lead to

acute renal failure and have been associated with lactic acidosis

in patients receiving metformin. Therefore withhold metformin for

at least 48 hours prior to and 48 hours subsequent to the procedure

Nifedipine

Co-administration increased plasma metformin Cmax and AUC

respy, and increased the amount excreted in the urine. Nifedipine

appears the absorption of metformin

Indication:

LIST OF DRUGS DURING 2006

Sr.No- 107

Name of the Drug- Glicazide 40mg/80mg+

Metformin Hcl 500mg

Rosiglitazone 2mg tablet Pharmacological Classification- Anti-diabetic

Date of Approval- 22-08-2006

Approved by U.S.FDA on 30-12-2006 (Ref- FDA approved List)

Type II -non insulin dependent diabetes not responsive to diet alone

Approved by (DCI) Drug Controller GENERAL - India For Marketing

(Ref- IDMA Publication)

Name of Drug Indication Date of Approval

1.Gliclazide Anti-diabetic November 1988

2.Glicazide 40mg/80mg 19-07-2010

+ Metformin 500mg

+ Pioglitazone 15mg

(Addl.Stgth.)

Anti-diabetic

3. Glicazide 40mg/80mg 22-08-2006

+ Metformin Hcl 500mg

+ Rosiglitazone 2mg tablet

Anti-diabetic

FIXED DOSE COMBINATIONS APPROVED BY DCG(I)

FROM JANUARY 1961 TILL NOVEMBER 2014

Name of Drug Indication Date of Approval

1.Gliclazide MR 30mg/60mg/80mg + 27-04-2005

Metformin Hcl 500mg/500mg/500mg ER tablet

For Type II Diabetes

Sulfonylureas- include- First generation - Acetohexamide, Chlorpropamide, Tolazamide, Tobutamide

Second generation - Glipizide, Glyburide ( Glibenclamide ), GlimepIride,Gliclazide

Refer Chlorpropamide

Adverse Reaction:

Severe hypoglycaemia,brain damage and death in the presence of renal/hepatic damage, malnutrition, anorexia, senility, alcohol intoxification, adrenal and pitutary insufficiency. Hypoglycaemia, GI disturbances, skin reactions, leucopenia, thrombocytopenia, agranulocytosis, hemolytic anaemia, chloestatic jaundice and GI haemorrhage.

Contra-Indications:

Juvenile onset diabetes,diabetes compilcated with ketosis,and acidosis, hypersens to other sulphonylureas, severe renal and hepatic impairment.

Unstable or brittle diabetes. Pregnancy and lactation.

Special precautions: Hypoglycaemia. May require insulins during metabolic stress. care when transfering from combination therapy.

Dosages/ Overdosage Etc:

Indication-

Type II -non insulin depedent diabetes not responsive to diet

Dosage-

Usually 2 tabs daily in divided doses , increase if required to 1-4 tabs in two divided doses depending on blood glucose results

Patient Information:

Sulfonylureas- include- First generation - Acetohexamide, Chlorpropamide, Tolazamide, Tobutamide Second generation - Glipizide, Glyburide ( Glibenclamide ), GlimepIride,Gliclazide Refer Chlorpropamide

GLIZA

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Drug Interaction:

Indication:

Adverse Reaction:

Contra-Indications:

Dosages/ Overdosage Etc:

Patient Information:

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