Data is not available on thiocolchicoside drug interactions Diclofenac interacts with aspirin, lithium, digoxin, methotrexate, cycosporin, cholestyramine and colestipol.

Low back pain Acute pain Inflammation and spasm

Photosensitivity reactions, gastro intestinal disturbances, head ache, dizziness, rash, gastric intestinal bleeding, peptic ulceration, abnormalities of kidney function

Hypersensitive to thiocolchicoside and diclofenac, Flaccid paralysis, muscular hypotonia, active peptic ulcer and 3rf trimester of pregnancy Children < 10 yrears

Low back pain Acute pain Inflammation and spasm

Pharmacokinetics-

After oral adminstration of 8 mg of thiocolchicoside to healthy volunteers no detectable thiocolchicoside was found in plasma, urine, or feaces, Diclofenac has fast onset and rapid and complete on oral administration. About > 99.5% binds extensively to plasma albumin. Peak plasma levels are acheived in 2 hrs . Half life of diclofenac sodium in plasma varies 1-3 hours

Rationale for combination-

NSAIDs and analgesics are ofteen used in combinations with muscle relaxants for symptomatic relief of LBP Hoewever, sedative effect limits the use of muscle relaxants. Thiocolchicoside being a non-sedating muscle relaxant, when used incombination with diclofenac a NSAID has shown to produce improved effect. The combination is well tolerated with less adverse efects.