Acarbose, anticoagulants , amiodarone, fat soluble vitamins, cyclosporin other anti-obesity agents (+/- 2hrs ) Anticonvulsants, iodine salts, Anti-diabetic , thyroid drugs may not need dose adjustments

Faecal urgecy/incontnence, oily stools, flatus with discharge, increased defecation, g-i upset, respiratory infections, influenza, headache, menstrual irregularities, anxiety, fatigue, UTI, raised liver enzymes, hepatitis, jaundice, severe liver injury, hepatocellular necrosis, acute hepatic failure, rectal bleeding

Chronic malabsorption, cholestatis pancreatic enzymes deficiency, chronic pancreatitis, major GI surgery lactation

Special precautions-

Exclude organic causes of obesity advice diet rich in fruit and vegetables containing approx. 30% calories, from fat fat soluble vitamin deficiency consider a multi-vitamin supplement monitor anti-diabetic drug treatment as diabetic patients lose weight possible failure of oral contraception due to severe diarrhea

Indication-

Adjunct to diet in obese patients 120mg before, during or upto 1 hour after each meal .

Discontinue treatment after 12 weeks if 5 percent of initial weight is not lost Not recommended for patients below 18 years

Adjunct to diet in obese patients

Observe caution Contraindicated for use during lactation and pregnancy.