None reported.

Eradication of scabies

Irritation,sensitive reactions, pallor and cyanosis and excessive application.

Acute exudative dermatitis

Do not use on fresh inflammed weeping skin disorders which call for moist treatment

Do not use on extensive areas in infants

Avoid eyes , mouth, and broken skin

Special precautions:

Should not be applied to eye, mouth other mucous membranes or on excoriated skin. Discontinue if severe irritation or sensitization occurs.

Pregnancy

Indications:

Eradication of scabies

Dosage:

Throughly massage into the skin of the whole body .

Second applicationn advisable after 24 hours.

             EVIDENCE BASED MEDICINE ( MIMS -April 2003)

                                Treatment of Scabies

                         Comparative effectiveness of various interventions

                                           Beneficial

1. Permethrin - cure rate of about 90%

Likely to be beneficial

1. Crotamiton

                                          Unknown effectiveness

1. Malathion

2. Benzyl benzoate - cure rate of about 50 percent

3. Oral ivermectin

4. Sulphur compounds

                                        Trade-off between benefits and harms

1. Gamma benzene hexachloride (lindane)

                                                   KEY POINTS

1. One systemic review of mainly small randomised clinical trials has found that topical permethrine and gamma benzene hexachloride has been linked to rare reports of serious side effects

2. There is limited evidence that crotamiton is safe but less effective than permethrine

3. There is insuffcient evidence on the effects of other topical agents (malathion, benzyl benzoate, and sulphur compounds). On the basis of case series, malathion acheived 80% cure rates but its safety has not been established

4. There is insufficient evidence on the effects of oral invercetin. It s known to be safe in adults based on the experience of its use in onchocerciaciasis, but its safety in elderly and children is uncetain

1. Shake well before use.

2. Patients with scabies should take a routine bath or shower.

3. Change clothing and bed linen the next day. Contaiminated bed linen and clothing may be washed in the hot cycle of washing machine.

4. Keep away from the eyes and mucous membranes. Do not apply to inflamed skin.

5. Discontinue use and notify physician, if irritation occurs.

Contraindicated Use with caution