Drug Interaction:
Benzodiapines include-
Alprozolam, Chlordiazepoxide, Clonazepam, Clorazepate,Diazepam, Halazepam, Lorazepam, Oxazepam, Prazazepam
Refer Diazepam
Anticonvulsants include-
Barbiturates, oxazolidinediones, Miscellanous
Phenobarbitone -Paramethadione Lamotrigine Trimethadione Primidone
Hydantions - Valproic acid Phenytoin
Benzidiazepines- Cabamazepine Mephenytoin Clonazepam Phenacemide Ethotoin Clorazepate Felbamate Diazepam Gabapentin
Succinimides - Ethosuximide Methsuximide Phensuximide
Refer Phenytoin -
Benzodiapines include-
Alprozolam, Bromozepam, Chlordiazepoxide, Clonazepam, Clorazepate,Diazepam, Estazolam, Flurazepam, Halazepam, ketazolam,Lorazepam,Nitrazepam, Oxazepam, Prazepam, Quazepam, Temazepam, Triazolam
Refer Diazepam
Drug interation- summary
+ Clonazepam
Barbiturate
increased clonazepam clearance occur, leading to lower steady-state levels and loss of efficacy
Valproic acid +Clonazepam or Clonazepam + Valproic acid
increased toxicity (drowsiness ) of clonazepam, reduced efficacy of both drugs
Indication:
Adjunct treatment of lennox-gastaut syndrome(petit mal variant),a kinetic and myoclonic seizures.
Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
1.Clonazepam Anti-epileptic January 1995
2.Clonazepam IR 0.5mg/0.5mg + 08-07-2010
Paroxetine CR 12.5mg/25mg
For the treatment of patients with Co-morbid depression and anxiety
Benzodiapines include-
Alprozolam, Bromozepam, Chlordiazepoxide, Clonazepam, Clorazepate,Diazepam, Estazolam, Flurazepam, Halazepam, ketazolam,Lorazepam,Nitrazepam, Oxazepam, Prazepam, Quazepam, Temazepam, Triazolam
Refer Diazepam
Anticonvulsants- Refer Phenytoin
Adverse Reaction:
Hypotension,apnoea,may be very serious when combined with alcohol,
Rare blood dyscrasias, thrombocytopenia.
Drowsiness, somnolence, fatigue, muscular hypotonia,
co-ordination disturbances, dizziness,
vertigo, anorexia, dyspepsia,visual and sleep disturbances,
loss of libido, impotence, abnormal thirst,
skin pigmentation,rashes and facial oedema.
Contra-Indications:
Hypersens to benzodiazepine,acute pulmonary insufficiency,
respiratory depression,lactation and pregnancy.
Special precautions:
Neonates,chronic pulmonary insufficiency,impairment of hepatic renal function, porphyria,elderly.
Dosages/ Overdosage Etc:
Date of Approval 1995
Indications:
Adjunct treatment of lennox-gastaut syndrome(petit mal variant),
a kinetic and myoclonic seizures.
Dosage:
Initial - not to exceed 1.5mg/day in 3 divided doses.
Increase in increment of 0.5 to 1mg every 3 days until seizures are adequately controlled. Maximum recommended dose is 20mg/day.
Children -(upto 10 yearss age)- initial -0.01 to 0.03mg/kg/day.
Not to exceed 0.05mg/kg/day in 2 or 3 divided doses.
Patient Information:
Benzodiapines include-
Alprozolam, Bromozepam, Chlordiazepoxide, Clonazepam, Clorazepate,Diazepam, Estazolam, Flurazepam, Halazepam, ketazolam,Lorazepam,Nitrazepam, Oxazepam, Prazepam, Quazepam, Temazepam, Triazolam
Refer Diazepam Anticonvulsants - refer Phenytoin
Pharmacology/ Pharmacokinetics:
Refer Diazepam Anticonvulsants - Refer Phenytoin
Pharmacology:
Clonazepam is a benzodiapine, is an efective anticonvulsant. It raises the threshold for propagation of seizure activity and prevents generalisation of focal or local activity.
Interaction with Food:
Take with or without food
Pregnancy and lactation:
Observe caution if required to be administered during pregnancy and lactation
Manufacturer Details