CNS depresants should be cautiously co-administered with ivermectin

Stronglyoidiasis Filiariasis, scabies

Stronglycidiasis -

CNS -    Dizziness 2.8% somnolence 0.9% vertigo 0.9% tremor 0.9%

Dermatologic-   Pruritus 2.8% rash 0.9% urticaria 0.9%

GI -  Anorxia 0.9% constipation 0.9% diarrhea 1.8% nausea 1.8% vomiting 0.9%

Hypersensitivity to ivermectin, trypanosomiasis, meningitis, pregnancy, children

Indications-

Stronglyoidiasis Filiariasis, scabies

Dosage-

Recommended dose - a single oral dose of 200mcg of ivermectin /kg body weight patients should take tablet with water

Ivermectin should be taken with water

Stronglycoidiasis- Patients should be reminded that of the need for repeated stool exam to document clearance of infection

Pharmacology:

It binds selectively and with high affinity to glutamate-gated chloride ion channels, which occurs in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to cholride ions with hyper polarization of the nerve or muscle cell in paralysis and death of the parasite

Pharmacokinetics:

Ivermectin is absorbed from the GI tract following oral administration. Peak plasma concentration is acheived in 4 hrs after administration. It is absorbed well on empty stomach. it is highly protein bound(93%).

It has long terminal half-life of 27 hrs and apparent volume of distribution of about 47 hrs. Ivermectin is metabolised in the liver and excreted in feces with less than 1% in urine and 2% in breast milk.

Well absorbed in a empty stomach

Use contrindicated during pregnancy