Brand Information

Updated On: 27-02-2024

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MYLEFAN

Brand:
MYLEFAN

Manufacturer:
CADILA PHARMA

Manufacturer Details
CADILA PHARMA

Compositions:
Busulfan 2mg tablets,

Strength	Rate	Packing Style
2mg	0.00	60s tablets

List of Related Indications:

Myeloid Leukaemia

List Of Drugs:

Busulfan - @ Alkylating agent

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Other Information

Patient Information

Pharmacology/ Pharmacokinetics

Interaction with Food

Pregnancy and lactation

Drug Interaction:

Alkylating Agents Includes-

Mechlorethamine ,Chlorambucil, Melphalan, Ifosamide,Cyclophosphamide, Urasil Mustard, Lomustine, Carmustine, Streptozocin, Thiotepa, Busulfan, Pipobroman, Cisplatin, Carboplatin

Immunisation with live viruses can cause threatening infection.

Combination with theoguanine results in nodular regenerative hyperplasia, portal hypertension, varices.

Cyclophosmamide enhances haemopoetic recovery.

Indication:

Alkylating Agents Includes-

Mechlorethamine ,Chlorambucil, Melphalan, Ifosamide,Cyclophosphamide, Urasil Mustard, Lomustine, Carmustine, Streptozocin, Thiotepa, Busulfan, Pipobroman, Cisplatin, Carboplatin

Adverse Reaction:

Bone marrow suppression, thrombocytopenia,

Second neoplasm.

G.I.symptoms, anorexia, weight loss, weakness,

severe fatigue, hyperpigmentation, amenorrhea,

cough, dysponea, catarats, epithelial dysplasis.

Contra-Indications:

Bone marrow supression.

Special precautions:

Lecopenia, anaemia, thrombocytopenia, previous irradications/cytotoxic therapy, hyperuricaemia.

Dosages/ Overdosage Etc:

Indications:

Palliative treatment of chronic myelogenic leukemia.

Dosage:

4 to 8mg/day is the total dose. 4mg/day is normal and higher doses is for most compelling patients.

Other Information:

Cataract-

Drugs causing adverse reactions-

1. Phenothiazines

2. Corticosteroids

3. Busulfan

4. Chlorambucil

Patient Information:

Busulfan - Systemic

1.Allergies-

Tell your doctor if you are have ever had any unusual or allergic reaction to

busulfan

2.Pregnancy-

Although one case has been reported, there is a chance that this medicine may

cause birth defects if either the male or the female is taking it at the time of

conception or if it is taken during pregnancy, In addition cancer medicines

may cause sterilty which could be permanent.Sterility may occur with busufan

and this possibility should be kept in mind.

It is best you discussed this with you doctor before taking this medicine. it is

best to use some kind of birth control while youn are taking busulfan. Tell your

doctor right away if you are pregnant while taking busulfan

3. Breast-feeding-

It is known whether busulfan passes into breast milk. However, because this

medicine may cause serious side effects, breast-feeding is generally not

recommended, while you are taking it.

4.Children-

Although there is no specific information comparing use of busufan in children

with use in other groups, this medicine is not expected to cause different side

effects or problems in children than it does in adults

5.Older adults-

Many medicines have not been studied specifically in older people. Therefore,

it may not be known whether they work exactly the same way than they do in

younger adults, or if they cause different side effects or problems in older people.

There is no specific information comparing use of busulfan in the elderly with use

in other age groups, this medicine is not expected to different side effects or

problems in elder people than it does in younger adults.

6. Other medicines-

Although certain medicines should not be used together at all, in other cases two

different medicines may be used together even if an interaction might occur.

In such cases your doctor may want to change the dose, or other precautions

may be necessary.

When you are taking busulfan it is especially important that your health care

professional know if you taking any of the following-

Amphotericin B by injection(eg Fungizone) or

Antithyroid agents (medicine for overactive thyroid) or

Azathioprine (eg,Imuran)

Chloramphenicol ( eg. Chloromycetin)

Colchicine or

Flucytosine (eg. Ancoban ) or

Ganciclovir (eg.Cytovene)

Interferon( eg. Inron A)

Plicamycin(eg.Mithracin ) or

Zidovudine (eg,AZT, Retrovir) or

If you have ever been treated with radiation or cancer medicines- Busufan may

increase the effect of these medicines or radiation therapy on the blood

Probenecid (eg.Benemid) or

Sulfinpyrazone (eg. Anturane ) Busulfran may raise the amount of uric acid in

the blood. Since these medicines are used to lower uric acid levels, they may

not effective in patients taking busulfan

7. Other medical problems-

The presence of other medical problems may affect the use of busulfan.

Make sure you tell your doctor if you have any other medical problems

especially-

Chicken pox ( including recent exposure ) or

Herpes zoster ( shngles) - risk of severe disease affecting other parts of

the body

Gout ( history of ) or

Kidney stones( or history of ) - busulfan may increase levels of uric acid

in the body, which can cause gout or kidney stones

Head injury or

Convulsions (history of ) - very high doses of busulfan can cause convulsions

Infection- busulfan may decrease your bodys ability to fight infection

Pharmacology/ Pharmacokinetics:

Pharmacology:

An alkylsulfonate, bisulfans predominant effect is against cells of the branulocytes series. Although polyfuntional alkylating agent, it apears to interact with cellular thiol groups.

Pharmacokinetics:

Busulfan is well absorbed following oral administration. The drug is extensively metabolised with little unchanged drug founfd in the urine.

Interaction with Food:

Take with chilled liquid, ensure adequate fluld intake

Pregnancy and lactation:

Refer Chlorambutil- Alkylating agent

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