Indication:
Acute monocytic and myleomonocytic leukemias.
Approved by FDA in 1983
Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
Etoposide Anti-cancer January 1988
Mitotic inhibitors include-
Etoposide, Vincristine, Vinblastine, Teniposide, Vinorelbine tartarate
Adverse Reaction:
Severe myleosuppression.
Nausea, vomiting,
Anorexia, diarrhoea,
Stomatitis, reversible alopecia.
Rarely disturbances of liver function,
Peripheral neuropathy.
CNS effects,
Anaphylactoid reactions.
Hypotension (with I.V.injection).
Patient Information:
Ref - USP PDI Vol II 17th Edition (1997)
1.Allergies-
Tell your doctor if you are have ever had any unusual or allergic reaction to
etoposide..
2.Pregnancy-
There is a good chance that this medicine will cause birth defects if it is being
used at the time of conception. It is best to use some kind of birth control while
you taking etoposide.
3. Breast-feeding-
Because etoposide may cause serious side effects, breast feeding is not
recommended while you are receiving etoposide
4.Children-
Although this medicine has been used in children, there is no specific information
comparing the use of etoposide in children with use in other age groups.
5.Older adults-
Many medicines have not been studied specifically in older people. Therefore,
it may not be known whether they work exactly the same way they do in
younger adults, or if they cause different side effects or problems in older people.
There is no specific information comparing use of etoposide in the elderly with use
in other age groups
6. Other medicines-
Although certain medicines should not be used together at all, in other cases two
different medicines may be used together even if an interaction might occur.
In such cases your doctor may want to change the dose, or other precautions
may be necessary.
Tell your doctor if you are using any of the following-
Amphotericin by injection
Chloramphenicol
Colchicine
Flucytosine
Gangiciclovir
Interferon
Pilacamycin
Zidovudine
If you have been treated with radiation or cancer medicine - etoposode
may interfere with the effects of these medicines or radiation therapy
on the blood.
7. Other medical problems-
The presence of other medical problems may affect the use of etoposide.
Make sure you tell your doctor if you have any other medical problems
especially-
Chickenpox or Including recent exposre)
Herpes zoster - risk of severe disease affecting other parts of the body
Infection- etoposide can decrease your bodys ability to fight infection.
Kidney disease or
Liver disease effects of etoposide may be increased because of slower
removal from the body.
Manufacturer Details