Patient Information:
Ref - USP PDI Vol II 17th Edition (1997)
TRIMETREXATE- SYSTEMIC
1.Allergies-
Tell your doctor if you have ever had any unusual or allergic reaction to
Timetrexate, metrexate or leucovorin. Also tell your healthcare care
professional if you are allergic to any other substances such as foods,
preservatives or dyes.
2.Pregnancy-
Use of trimetrexate during pregnancy should be avoided whenever
possible since trimethotrexate has caused birth defects of the fetus in
animal studies. Use of birth control is recommended during trimethrexate
therapy. Tell your doctor if you think you are pregnant or if you need advice
on birth control
3. Breast-feeding-
It is not known whether trimetrexate passes into breast milk. However,
breast feeding should be stopped during treatment with this medicine,
since the medicine may cause unwanted effects on nursing babies
4.Children-
This medicine has been tested in a limited number of children younger than
18 years of age. Trimetrexate can cause serious side effects in any patient.
However, in effective doses this medicine did not cause different side effects
or problems than it does in adults.
5.Older adults-
There is no specific information comparing use of trimetrexate in the elderly
with use in other age groups.
6. Other medicines-
When you are taking trimetrexate it is especially important that your doctor
know if you are taking any of the following-
Acetoaminophen or
Amiodarone or
Anabolic steroids or
Androgens or
Carbamazepine or
Dantrolene or
Estrogens or
Hydroychloroquine or
Methyldopa or
Use of these medicines may increase the chance of side effects
7. Other medical problems-
The presence of other medical problems may affect the use of
trimetrexate. Make sure you tell your doctor if you have any other
medical problems especially-
Anemia or
Low platelet count or
Low white blood cell count - trimetrexate may make the blood diseases
you have worse.
Kidney disease or
Liver disease - kidney or liver disease may increase the chance of
side effects from trimetrexate
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