Avoid aspirin other pain relievers increased risk of GI bleeding with alcohol

Myalgia Burns, aches and pain

Dyspepsia, GI bleeding Rash, abdominal pain Nausea, vomiting Drowsiness Lightheadedness

Aspirin/anti-inflammatory allergy History of active peptic ulceration Children below 12 years Pregnancy suicidal tendencies

Special precautions- Asthma, bleeding disorders Cardiovascular diseases and those receiving coumarin anticoagulants Alertness may be impaired during first few days of therapy Renal or hepatic impairment Monitor hepatic function on long term therapy Lactation not recommended

Indication-

Myalgia Burns, aches and pain

Dosage-

1 cap thrice daily

EVIDENCE BASED MEDICINE (April 2003) Pain of Osteoarthiritis Comparative effectiveness of various interventions

Beneficial

1. Systemic simple analgesics (eg paracetamol for short term pain relief, and improvement in function)

2. Systemic NSAIDs (short term pain relief and improvement in function)

3. Topical agents (short term pain relief)

Likely to be beneficial

1. Education, dietary advice,empowerment and support ( improved knowledge of disease and pain relief)

2. Physical support (pain relief and improvement in function)

KEY POINTS

1. There is no good evidence that NSAIDs were superior to simple analgesics such as paracetamol or to suggest that any one of the many available NSAIDs had greater efficacy in relieving pain of osteoarthritis.

2. One systematic review of randomised controlled trials has found that topical agents provide pain relief in patients with osteoarthritis and offer a non-toxic alternative to systemic drug treatment. However there is no evidence to indicate whether the prescribed agents were superior to less expensive, non-prescribtion drugs over the counter (OTC) alternatives, or to other local treatments such as hot or cold packs.

Contrindicated for use during pregnancy and lactation Observe cauition if required to be used