Drug Interaction:
Thiazides and related diuretics include-
Bendroflumethiazide, Benzthiazide, Chlorthiazide, Hydrochlorthiazide, Hydroflumethazide,
Indapamide, Methyclothizide, Metolazone, Polythiazide, Quinethazone, Trichlormethiazide
Refer Hydrochlorthiazide- Thiazide and related diuretics
Indication:
U.S.FDA APPROVED DRUGS FROM 01-01-08 TO 31-12-08
Drug name Indication Date of Approval
138. Metalazone 2.5mg 28-05-08
+Losartan potassium 25mg/50mg tablets
For hypertension in patients whose blood pressure
is not adequately controlled by monotherapy
139. Metalazone 2.5mg 28-05-08
+ Ramipril 2.5mg/5mg
For essential hypertension in adult patients
whose blood pressure is not adequately controlled
by monotherapy
184. Metolazone 25-08-08
+ Spironolactone FC tablets (2.5/5mg+50mg)
(Addl.stgth)
For the treatment of odema associated with congestive
heart failure, cirrhosis and nephtitis syndrome
Approved by (DCI) Drug Controller GENERAL - India For Marketing (Ref- IDMA Publication)
Name of Drug Indication Date of Approval
1.Metalazone Diuretic 23-04-2003
2.Metalazone 25-08-2008
+ Spironnolactone FC tablets
2.5mg +50mg
For the treatment of oedema associated with congestive heart failure,
cirrhosis and nephrotic syndrome
3.Metalozone 2.5mg 28-05-2008
+ Losartan potassium 25mg/50mg tablets
For Hypertension in patients whose blood pressure is not adequately
controlled in monotherapy
4.Metalozone 2.5mg 28-05-2008
+ Ramipril 2.5mg/5mg
For essential hypertension in adult patients whose blood pressure
is not adequately controlled on monotherapy
Edema, hypertension
Thiazides and related diuretics include-
Bendroflumethiazide, Benzthiazide, Chlorthiazide, Hydrochlorthiazide, Hydroflumethazide,
Indapamide, Methyclothizide, Metolazone, Polythiazide, Quinethazone, Trichlormethiazide
Refer Hydrochlorthiazide- Thiazide and related diuretics
Patient Information:
Thiazide diuretics
1. May cause GI upset, may be taken with food
2. Drug will initially increase urination which should subside after a few weeks, take early during the day or as
directed
3. Notify physician, if muscle pain,weakneess or cramps, nausea, vomiting, restlessness, excess thirst,
tiredness, drowsiness, increased heart rate or pulse, diarrhea, or dizziness occurs
4. May cause photosensitivity (sensitivity to sunlight). Avoid prologed exposure to the sun and other
ultraviolet light.
Use sunscreens and wear protective clothing until tolerance is determined
5. May increase blood sugar levels in diabetes
6. Do not drink alcohol or take other medications without physicians approval, this includes
nonprescription medicines for appetite control, asthma, colds, cough,hay fever or sinus
7. Do not interrupt , discontinue or adjust the dose, even if feeling well. Follow physicians instruction
regarding missed dose.
Pharmacology/ Pharmacokinetics:
Thiazides and related diuretics include-
Bendroflumethiazide, Benzthiazide, Chlorthiazide, Hydrochlorthiazide, Hydroflumethazide,
Indapamide, Methyclothizide, Metolazone, Polythiazide, Quinethazone, Trichlormethiazide
Refer Hydrochlorthiazide- Thiazide and related diuretics
Manufacturer Details