Prophylaxis against Hepatitis B infection

 

Local- injection sites soreness, erythma, swelling, warmth, induration, pain, tenderness, pruritus,  ecchymosis, nodule formation

GI- nausea, vomiting, abdominal pain/ cramps, dyspepsia, diminished appettite, anorexia, diarrhea, abnormal liver function tests.

CNS- headache, lightheadedness, vertigo, dizziness, paresthesia, insomnia, disturbed sleep, somnolence, irritability, agitation, migraine, syncope, paresis, neuropasthy including hypoesthesia,  Gullian Barre syndrome, Bells palsy, traverse myelitis.

Respiratory- pharyngitis, upper respiratory infection, rhinitis, influenzaloke syndrome, cough,  bronchospasm.

Musculoskeletal- arthalgia, myalgia, back, neck and shoulder pain, neck stiffness

Dermatologic- pruritus, rash (non specified ) angioedema, urticaria, petechiae, erythema, ezema,  purpura, herpes zoster

Body as a whole- fatigue/weakness, fever, > 100F, malaise, sweating, achiness, sensation of warmth,  chills, flushing , iritability , tingling.

Miscellaneous- lymphodenopathy, earache, hypotension, dysuria, tachycardia, palpitations,  thrombocytopenia, conjuntivitis, keratitis, visual disturbances
 

Hypersenstivity to yeast

Special Precautions-
Infection- serious active infection is raeson to dealy use of Hepatitis B vaccine, except when withholding the vaccine entails greater risk.

Special risk patients- cautiously administer to individuals with severely compromised cardiopulmonary status or when a febrile or systemic reaction could be a significant risk.

Warnings-
Hypersensitivity- have epinephrine 1:1000 immeiately avilable.

Immunosuppressed patients- may require large vaccine doses and may not respond as well as healthy individuals.

Limitations- no hepatitis B vacine will protect against hepatitis A,C, and E viruses or other viruses  known to infect the liver.

Elderly- immunogenicity of hepatitis B vaccine is some what reduced in persons > 40 years of age.

Pregnancy-

Safety for use during pregnacy has not been established. Use only when clearly needed.

Lactation- safety for use in the nursing mother has not been established.

Children- Hepatitis B is well tolerated and highly immunogenic ininfants and children of all ages.  Newborns also  respond well.
 

Prophylaxis against Hepatitis B infection

Dosage-
For IM use.never inject IV. The deltoid muscle is the preferred site in adults. Injections given in the
 buttocks frequently are given into fatty tissue instead of into muscle and have resulted in lower
seroconversion rate than expected.



Missed dose-

1. If you miss a dose of this medicine, and remember it on the day it should be taken, take it as    directed.

2. However, if you do not remember the mised dose until the next day,take  the missed dose at that time and    reschedule your every-other-day doses from then.

3. It is important that this vaccine be taken exactly as directed so that it can give you protection against Hepatitis.

Pharmacology-

The recombinant heaptitis vaccines are derived from HBsAg prodicts in yeast cells. Hepatitis B vaccine induces protective anti-HBs in most individuals receiving the recommended three-dose regimen. .

Pregnancy-

Safety for use during pregnacy has not been established. Use only when clearly needed.

Lactation-

Safety for use in the nursing mother has not been established. Children- Hepatitis B is well tolerated and highly immunogenic ininfants and children of all ages. Newborns also respond well.