Aminoglycosides, cephaloridine, colistin

Serious Gram -positive infections.

Serious staphylococci infections in patients sensitive or unresponsive to penicilins or cephalosporins

Local reaction s at injection site , thrombophebitis, rash, fever, rigor, bronchospasm, Anaphylaxis, GI upset Angioedema, exoliative dermatitis Arythrema multiforme.

Dizziness, mild hearing loss, vestibular disorders, Tinnitus, headache,

Blood dyscrasias Increase in serum transminase

Alkaline phosphatase and creatinine Renal failure, superinfections

Hypersensitivity to vancomycin Prolonged use ( monitor renal, hepatic, haematological & auditory tests )

Pregnancy Lactation

Elderly

Renal impairment, superinfection

Indication-

Serious Gram -positive infections.

Serious staphylococci infections in patients sensitive or unresponsive to penicilins or cephalosporins

Dosage-

Moderate infections - 400mg i.v. or i.m. as a single dose on first day and then 200mg i.v. or i.m. daily

Severe infections - 400mg i.v. every 12 hours for 3 doses then 400mg i.v. or i.m. daily. over 85 kg body weight 3-6mg /kg

Reduce dose from fourth day in renal insufficiency

Prophylaxis in orthopedic surgery- 400mg i.v. as a sngle dose at induction of anesthesia

Children - neonates 16mg/kg body weight as a single dose i.v. infusion over 30 minutes on first day then 8mg/kg body weight as a single dose

Observe caution Contraindicated for use during pregnancy and lactation