Fluoroquinolones include the following : Ciprofloxacin, Norfloxacin, Lomefloxacin, Ofloxacin, Pefloxacin, Enoxacin Refer Ciprofloxacin

Theophyline kinetics may be altered by concomitant use of pefloxacin. Increased anticoagulant effects of warfarin. Cyclosporin blood levels increased, convulsions may be precipitated by concurrent admin of NSAID,s. Rifampicin may reduce serum levels, Iron inhibits absorption Antacids reduce absorption of many quinolones. Milk and milk products may reduce absorption of pefloxacin.

Susceptible infections

Fluoroquinolones include the following : Ciprofloxacin, Norfloxacin, Lomefloxacin, Ofloxacin, Pefloxacin, Enoxacin Refer Ciprofloxacin

Pseudomembranous colitis and superinfections. Nausea, vomiting, gastric pain, confusion, Disorientation, abnormal movements, Skin reactions and photosensitisation.

Hypersens to quinolones including pefloxacin, Children under 15 years, glucose 6-phosphatedehydrogase deficiency, Pregnancy and lactation.

Special precautions: History of convulsions, raised CNS damage and intracranial pressure, toxic psychosis, Severe cerebrovascular disease, Severe liver disease, elderly, Excessive exposure to sunlight during and 5 days after cessation of therapy.

Dosage-

400mg bid Acute uncomplicated cystitis in women Gonoccocal urethritis in men 800mg bid

Classification: Anti-Bcacterial Patent position: Expires 28 May 1998 Major brands: IFIPEP UNIQUE PEFBID ALEMBIC PELOX WOCKHARDT MARKET LEADER PIFLASYN RHONE-POULENC PROFLOX EYE PROTEC Raw materials:

1.Chloro fluoroaniline

2.Ethoxy methylene malonic acid ester(EMME)

3.Chloro fluro dihydro oxo carbethoxyquinoline(Cyclizate)

4.Ethyl bromide

5.Dimethyl sulfoxide

6.Ethyl chloro fluro dihydro oxo quinoline carboxylic acid

7.Methane sulfonic acid

Refer fluoroquinolones

Refer fluoroquinolones

Rate of absoption reduced

Use contraindicated. Observe caution