Additive effect with sodium retension caused by hydrocorticosteroids. Potentiates renal excretion of tetracyclines. Hypochloraemic alkalosis may occur if used in conjunction with potassium depleting diuretics.

May increase half-life of basic drugs like quinidine, amphetamines, ephedrine and pseudoephedrine. Reduce nephrotoxicity caused by methotrexate. Enhances elimination of salicylates and barbiturates.

Metabolic acidosis

Over dose or too rapid administration can cause metabolic alkalosis (especially in renal impairment).

Stomach cramps and flatulance. False positive sticks for proteins.

Where sodium salt is contraindicated like hypertension,and oedema, hyperosmolar states.

Special precautions:

Hypoventilatory states, hypocalcaemia, alkalosis, renal disease, neonates.

Indication-

Metabolic acidosis

Dosage-

5-10ml children 2ml all 3-4 times daily