Terbinafine hcl 250mg tablets,
List of Related Indications:
- Dermatos-sec mxd fung/bact inf
List Of Drugs:
- Terbinafine hcl ( ** ) - @- Topical anti-infective- (1992)
Indication Type Description:
Dosages/ Overdosage Etc
Pregnancy and lactation
Irritation, burning, itching, dryness.
Oral- Severe neutropenia, allergic reactions( including anaphylaxis), taste disturbance.
Hypersen. Patients with pre-existing liver disease or renal impairment.
Monitor CBC in immunodefiency patients receiving treatment for more than 6 weeks .
Dosages/ Overdosage Etc:
Approved by FDA on December 30,1992
Skin and nail infections
Oral- Onychomycosis- Fingernail - 250mg/day for 6 weeks.
Toenail- 250mg/day for 12 weeks.
Storage: store between 5 and 30C(4 and 86F). Store tablets below 25C.
Protect from light
Terbinafine is a synthetic allylamine derivative, which exerts fungal effect by inhibiting squalene epioxidase, a key enzyme in sterol biosynthesis in fungi.
Terbinafine is well absorbed and peak plasma concentration of 1mcg/ml appear within 2 hour of after a single 250mg dose. Pror to excretion, terbinafine is extensively metabolised. Approximately 70% of the administerd drug is eliminated in the urine.
Pregnancy and lactation:
No adequte and well controlled studies in pregnant women available. Use only if clearly indicated during pregnancy
Excreted in breast milk. Decide whether to continue the drug or discontinue nursing, taking into account the importance of the drug to the mother.