FEVRIDOL
ZUVENTUS
ZUVENTUS HEALTHCARE LTD 3101-3108 3RD FLOOR BUILDING 3C OBEROI GARDEN ESTATE CHANDIVILILI ANDHERI EAST MUMBAI 400072
zuventus@rediffmail.com
Paracetamol 1000mg/100ml infusion,
Strength | Rate | Packing Style |
---|---|---|
1000mg/100ml | 328.60 | 100ml infusion |
List of Related Indications:
- Mild to moderate pain
List Of Drugs:
- Paracetamol -Plain @ -( Acetoaminophen )- Analgesics- (FDC- List ) - (1972)
Indication Type Description:
Drug Interaction
Indication
Adverse Reaction
Contra-Indications
Dosages/ Overdosage Etc
Patient Information
Drug Interaction:
Paracetamol-
Reduced absorption of cholestyramine within 1 hour of administration
Accelerated absorption with metoclopromide
Decreased effects of barbiturates, carbamazepines, hydantoins, ripampicin,
and sulfinpyrazone
Paracetamol increase effect of warfarin
Paracetamol increase risk of liver damage in chronic alcoholics ,
Increased risk of toxicity with other hepatotoxic drugs or drugs which induce
microsomal enzymes eg. barbiturates , carbamazepine , hydantoins,
ripampicin, sulfinpyrazone
Indication:
Moderate to severe pain
INFORMATION -UPDATE
US- PARACETAMOL DOSE REDUCED IN FDCs
The United States Food and Drug Administration (USFDA) has ordered the reduction of
paracetamol to 325mg per dose for adults in Fixed-Dose Combination (FDCs) products
to reduce liver toxicity.
Paracetamol is permitted to be combined with aspirin and opiods ( codeine, pentazocaine
and tramadol ) only in the United States
The action has been taken since both paracetamol and opiods cause liver injury. (MIMS).
Adverse Reaction:
Nausea, allergic reactions, skin rashes, acute renal tubular necrosis
Very rare dyscrasias eg. thrombocytopenia, agranulocytosis, liver damage
Contra-Indications:
Special precautions/warnings-
Renal or hepatic impairment
Alcohol-dependent patients
G6PD deficiency
Dosages/ Overdosage Etc:
Date of Approval 1972
Indication-
Moderate to severe pain
Dosage-
Paracetamol-
Adult- 0.5 to 1g 4-6 hourly as necessary. Max 4g daily
Child- neonate- 28 to 32 weeks
post menstrual age- 20mg/kg as a single dose
then 10-15mg /kg 8-12 hourly ( max 60mg/kg daily in divided doses
child - 1-3 mths - 30mg 8 hourly (max 60mg/kg daily in divided doses )
3mth to 1 year - 60-120mg 4-6 hrly 9max 4 doses in 24 hours
1-5 years - 120-250mg 4-6 hourly (max 4 doses in 24 hours )
6-12 years - 250- 500mg 4-6 hourly 9max 4 doses in 24 hours
Patient Information:
Acetoaminophen - commonly used names are APAP and Paracetamol
1. Allergies- Tell your doctor if ever you had any unusaual allergic reactions to
acetoaminophen or aspirin. Also tell, your doctor if you are allergic to any other substances
such as foods, preservatives or dyes.
2. Pregnancy - acetoaminophen has not been reported to cause birth defects or other
problems.
3. Breast feeding- it has not been reported to cause problems in nursing babies
4. Elderly- acetoaminophen has not shown to cause different side effects or problems
in older people than it does in younger adults.
5. Other medicines- certain other medicines should not be used together at all, in other
cases two different medicines may be used together even if interaction might occur.
Tell your doctor if you are taking any other prescription or non-prescription ( OTC )
medicines.
6. Other medical problems - presence of other medical problems may affect the use of
acetoaminophen . Make sure you tell your doctor if you have any other medical
problems -
Alchol abuse, Kidney disease,
Hepatitis or other liver disease - chance of serious side effects may be increased.
Phenylketonuria - some brands of acetoaminophen may contain aspartame, which
can make the condition worse.
7. Dosing- follow your doctors advice or directions given on the label. If your dose
is different do not change it unless your doctor tells you to do so