Drug Interactions- summary-

Increased effects of effects with cyclosporine

Increased incidence of hepatotoxicity with rifampicin

Tuberculosis

Anorexia , excessive salivation
Metallic taste,

Nausea, vomiting,
Abdominal pain, diarrhoea,

Peripheral or opic neuritis,
Psychiatric disturbances eg depression, anxiety,

Psychosis, postural hypotension,
Jaundice, hepatitis,

Thrombocytopenia, skin rashes,
Stomatitis, gynaecomastia

Hypersensitivity,
Severe hepatic disease, porphyria

Special precautions-
Difficulty in managing DM,

Monitor blood glucose, thyroid and visual function,

Perform LFT  before and during treatmentwith prothionamide

Caution inpatients psychiatric illness or depression

Pregnancy, lactation

Indication
Tuberculosis

Dosage-

Adult- as second line drug-

500- 750mg  daily after meals in 2-3 divided doses along with other anti-tubercular drugs
Max 1 g daily

Child- as a second line drug-
10-20mg/kg  as a single dose
Max 750mg daily

Observe caution