Drug interactions - summary

Tinidazole -
 Synergism with ampicillin , doxycycline  and co-trimoxazole
 disulfram -like reaction with alcohol

Fluconazole -
Rifampicin reduces fluconazole levels
increases concentration of hypoglycaemics

Theophylline-                                                                                                                reduces theophylline clearance

Oral contrceptives-                                                                                                                  affects effects of oral contraceptives

Sulponylureas and phenytoin-                                                                                         may raise serum concentration of oral sulponylureas and phenytoin

Cyclosporine-                                                                                                        cyclosporine levels may be increased

Warfarin-                                                                                                                          effects of warfarin and other anticoagulants may be increased

Cisapride-                                                                                                                            increased risk of cisapride toxicity

Aztemizole , cisapride or terfenadine-                                                                              cardiac arrhyhtmias with aztemizole , cisapride or terfenadine

Vaginal Candidiasis

Metallic taste, nausea, headache, vomiting, rash ( rare)

Thrombophelbitis at inj site, leucopenia, abdominal pain,
diarrhoea, flatlutance, elevated liver function values

rash, exfoliative dermatitis,
rarely, angioedema, anaphylaxis, facial and laryngeal edema,

hypotension, bronchospasm, hepatotoxicity,

very rarely , stevensons syndrome

Hypersensitivity,blood dyscarasias, organic neurological disorders

pregnancy, lactation

Special Precautions-

Renal or hepatic impairment
Avoid alcohol

Indications-

Vaginal Candidiasis

Dosage-

Adult - 1 kit of combination once a day

Use contraindicated . Observe caution