Concuurrent use increases risk of blood dyscrasias with azothioprine, methotrexate, pyrimethamine,

Increased risk of hyponatraemia when used with both pot-sparing diuretics and thiazides

Increases risk of bleeding with warfarin Increase risk of lithium toxicity Increases digoxin, phenytoin, procainamide , lamivudine, stavudine, repaglidine, rosaglitazone, dofetilide serum levels Decrease ciclosporin levels

Concurrent use with with dapsone increase serum levels of both and increases risk of dapsone toxicity

Concurrent use may potentiate antidiabetic effect of sulphonylureas Concurent use increases risk of dyscrasiasis with clozapine and pyrimethazine

Respiratory tract infections Skin infections. Urinary tract infections Ear, nose, throat infections

Nausea, vomiting Anorexia, diarrhoea, glossitis Stomatistis, Drowsiness, headche, deptession, hallucinations, Hypersensitivity, skin reactions, Drug fever, crystalluria, Elevation of liver enzymes, Hypothyroidism, hyponatemia, Hyperkalemia, kernicterus in premature neonate, Aseptic menignitis, chloestatic jaundice, Anaphylaxis, Stvens- Johnson syndrome Blood dyscrasis eg agranulocytosis, Aplastic anemia, Toxic epidural necrolysis

Hypersentivity to sulfonamides Severe renal or hepatic mpairment Porphyria, SLE, Serious hzaematogical disorders

Megaloblastic anemia Secondary to folate depletion Infants < 2mths Pregnancy ( 3rd trimester ) Lactation

Special precautions-

Renal insufficiency , elderly, blood dysctasis, G6PD deficiency, Patients with folatev defeciency Child with fragile chromosome associated with mental retardation Perform regular haematological examination

Respiratory tract infections Skin infections. Urinary tract infections Ear, nose, throat infections

Dosage-

Initially 2 tabs followed by 1 tab bid

Observe caution if required to be administered during pregnancy and lactation Pregnancy ( 3rd trimester ) Lactation