Atorvastatin- increases in digoxin levels increases in anticogulant effect of warfarin

Avoid combination of MHG-Co A reductase inhibiotors and fibrates

Ezetimibe- Chloestyramine decreases AUC of ezetimibe by approx 55%

Cycosporin may increase ezetimbe levels antacids decrease atorvastatin levels

Colestipol decreases atorvastain plasma levells.

Propranol decreases antihyperlidaemic activity of atorvastatin

Hypercholesterolaemia

Headache, flatulence dyspepsia myalgia,

rash pruritus, allergy and infection

Abdominal discomfort asthenia,

constipation diarrhoea,

back pain arthalgia,

respiratory infection

fatigue

Hypersensitivity active liver disease or unexplained persistent elevated liver function tests

Pregnancy Lactation

Special Precautions-

hepatic impairment patients consuming substantial quantities of alcohol and history of liver disease

Not recommended for children < 12 yeras

Indication-

Hypercholesterolaemia

Dosage-

1 tab daily

Use contraindicated

Observe caution