Nondepolarizing Neuromuscular Blockers include-

Pipercuranium, Vecuronium,Doxacuranium, Tobocurane, Mivacuranium,Rocuronium, Cisatracurarium, Atracurarium,Pancuronium

Refer- Pancuronium

An adjunct to general anesthesia

Indications

An adjunct to general anesthesia

Dosage-

Individualise dose

Surgery - in an averge weight patient, give 40 to 60 units IV when incison is made.

Overdosage-

Symptoms

Extended skeletal muscle weakness, decreased respiratory reserve, lower tidal volume, prolonged apnea, cardiovascular collapse and sudden release of histamine. sufficiently excessive doses of nondepolarizing muscle relaxants have no antidote.

Treatment

1. A peripheral nerve stimulator may be used to assesss the degree of residual neuromuscular blockade .

2. For residual neuromuscular blockade with respiratory paralysis or inadequate ventilation, maintain airway and administer manual or mechanical ventilation.

 Missed dose-

1. If you miss a dose of this medicine, take it as soon as possible.

2. However, if it is almost time for next dose, skip the missed dose and go back to your regular dosing schedule.

3. Do not double doses.