Preliminary results suggest that concomittant admin. of a wide variety of other vaccines is unlikely to interfere with the immune response to hepatitis A vaccine When comcomittant admin. of other vaccines or IG is required, they should be given with different syringes and at different injection sites

Adverse events to hepatitis are usualy mild & confirmed to the first few days after vaccination wit spontaneous recovery.

Local- pain at the site of action, redness, swelling hematoma, irritations/edema, pruritis.

These usually subside within 72 hrs and no specific treatment is needed. Relevent trreatment may be given whenever needed.

Systemic- Fever . 37.5c axillary,asthenia/drowsiness.headache, myalgia, arthalgia, gastrointestinal disorders, behavoiural changes, skin disorders

Contraindications-

Hyperacidity to the vaccine or any component of formulation Acute infection diseases or other serious ilness Acute febrile illness with temperatures above 37.5C Immunodificiency status A history of anaphlaxis or any other serious allergic reaction to vaccines A monor a febrile illness or mild upper respiratory tract infection is not usually a reason to defer immnization with the vaccine

Indication-

Active imunization against infections caused by HAV in persons over 1 year age

Dosage-

Add 1.0 ml sterile water fot injection & shake well the powder completely dissolves. Then inject a single dose of 1ml subsequently over the deltoid muscle of upaer arm. No boster dose ie required

Fully inform patients or guardians of th benefits and risks of imunization Hepatitis A vaccine is indicated for a variety of situations.

For persons travelling to endemic or epidemic areas, consult the local advisory regarding specific locales Travellers should take al necessary precautions to avoid contact with or ingestion of contaminated food or water The duration of immunity following a complete schedule of immunization with Hepatitis a vaccine has not been established

Pharmcokinetics-

Hepatitis A confers immunity against HIV infection by the induction of specific antibodies against the virus. The vaccine confers immunity against HAV virus by including antibodies titres than those obtained after passive immunization with immunoglobulins.