Resperpine- Hypotensive effects enhanced by thiazide diuretics and other antihypertensives may cause excitation & HTN with MAOIs . May cause cardiac arrhythmias with digitalis or quinidine. Effects of CNS depressants may be enhanced May decrease patients response to levodopa

Reserpine Hypertension

Reserpine- Nasal congestion, headache, CNS disorders, GI disturbances Breast engorgement Galactorrhoea Gynaecomastia Decreased libido Impotence Na retention, decreased/increased appetite Weight gain, Miosis Dry mouth, sialorrhoea Dysuria, rashes, pruritus, thrombocytopaenic purpura

Reserpine- Active peptic ulcer or ulcerative colitis Depression Parkinsons disease Pheochromocytoma Electrconvulsive threrapy ECT

Reserpine- Hypertension

Dosage-

Adult - 500mcg daily for about weeks subsequently reduced to lowest dose necessary to maintain response Maintenance 100 to 250mcg daily. Maximum dose - 500mcg daily

REFER - RESERPINE+DIHYDRALAZINE+HYDROCHLORTHIAZIDE