Drug Interaction:
Interacting drugs- summary
Sulphadoxine +
Antifolic drugs eg /pyrimethamine/ methotrexate, Sulfonamides TMP-- SMZ-
do not use while the patient is receiving sulfonamide for antimalarial prophylaxis
Indication:
Falciparium malaria
Adverse Reaction:
Stevens-Jhonson syndrome, generalised toxic epidermolysis, fatal hepatic failure(rare). GI symptoms, feeling of fullness, stomatisis, rash, pruritis, Hair loss, leucopenia, Thrombocytopenia, megablastic anaemia, Fatigue, headache, Fever, polyneuritis, Orthostatic hypotension.
Contra-Indications:
Severe renal impairment, severe liver parachymal damage, blood dyscrasias, hypersensitivity to components, megaloblastic anaemia due to folate deficiency, pregnancy at term and during lactation, infants less than 2 months old.
Special precautions:
Impaired renal or hepatic function, folate deficiency, severe allergy or bronchial asthma, G6PD deficiency.
Dosages/ Overdosage Etc:
Indications:
Falciparium malaria
Dosage::
Acute attacks- Adults - 2 to 3 tablets Prophylaxis- 1 tablet once daily
Patient Information:
1. Maintain adequate fluid intake to prevent crystalluria and stone formation.
2. Notify physician, if any unusual symptoms occur
3. At the first appearance of skin rash, discontinue the drug
4.Take contraceptive measures to avoid pregnancy during therapy.
5. Avoid breast feeding during therapy.
Ref - USP PDI Vol II 17th Edition (1997)
SULPHADOXIME AND PYRIMETHAMINE - SYSTEMIC
1.Allergies-
Tell your doctor if you have ever had any unusual or allergic reaction to
sulfa medicines. Also tell your healthcare care professional if you are
allergic to any other substances such as foods. preservatives or dyes.
2.Pregnancy-
Women who travel to an area where there is a chance of getting malaria
and who may be taking sulfadoxime and pyrimethamine combination,
should not become pregnant
3. Breast-feeding-
This medicine is not recommended for use during breast-feeding.
4.Children-
Sulfadoxime and pyrimethamine combination should not be used
in infants up to 2 months of age.
5.Older adults-
There is no specific information comparing use of sulfadoxime and
pyramethamine combination in the elderly with use in other age
groups.
6. Other medicines-
When you taking sulfadoxime and pyrimethamine combination it
is especially important that your healthcare professional know if
you are taking any other medicines
7. Other medical problems-
Make sure you tell your doctor if you have any other medical problems
Pharmacology/ Pharmacokinetics:
Pharmacology:
Sulfadoxime/pyremethamine is an antimalarial agent which acts by reciprocal potentiation of its components, acheived by a sequential blockade of two enzymes involved in the biosynthesis of folinic acid within the parasites.
Pharmacokinetics:
Both are orally absorbed and excreted mainly by the kidneys. Following a single tablet, sufodoxime peak plasma concentrations of 51 to 76mc/ml are acheived in 2.5 to 6 hours and pyrimethine peak plasma concentration of 0.13 to 0.4mcg/ml are reached in 1.5 to 8 hours.
Interaction with Food:
Report not available
Pregnancy and lactation:
Pregnancy:
Use during pregnancy only if potential benefits outweigh the potential risk to the fetus.
Lactation:
Both drugs appear in breast milk. Discontinue nursing during therapy.
Children:
Do not give to infants below 2 months of age.
Manufacturer Details