Drug Interaction:
Interacting drugs- summary
+Oral Poilo Virus Vaccine( OPV)
Immunosuppressants
administration of OPV to patients receiving immunosuppressants,
including corticosteroids or radiation therapy,result in
insufficient response to OPV.
They may remain susceptible despite immunization.
Vaccines others
cholera vaccine rduced the seroconversion rate to OPV Type 1 vaccine
in one study. Separate 1 month if possible. Several routine vaccines
may be given simultaneously at separate sites
(eg, leg, DTP, MMR, Hib, Hepatitis B)
Indication:
Selective immunisation against polio
Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
Oral Polio Vaccine Polio Vacccine oral May 1992
(Verocell)
Adverse Reaction:
Vaccine associated paralysis- occurs with a frequency of 1 case per 2.6 million OPV doses.
Contra-Indications:
Defer immunizatin in the presence of any acute illness, persistent vomiting or diarrhea and in patients with any debilated condition.
Any person with immunosuppression or any household member of an immunodeficient person.This includes those with combined immnuodeficiency , hypogammagloulinemia,agammaglobulinemia, thymic abnormalities, leukemia,lymphoma, generalized malignancy, loweredresistence to infection from therapy with corticosteroids, alkylating drugs,amntimetabolites orradiation.
Advice vaccine recepients to avoid such persons for at least 6 to 8 weeks.
To preclude vaccine-asociated disease, do not give OPV to a member of a household in which there is a family history of immunodeficiency until the immune status of the intended receipient and other children in the family is determined to be normal.
Warnings-
Poliomylitis- OPV is not effective in modifying or preventing cases of existing or incubating
poilomyletis.
Immunodeficiency- do not use in immunodeficient persons, including persons with congenital or acquired immune defeciencies, whether due to genetics, disease or drug or radiation therapy. Contained live virus. Polio virusis shed for 6 to 8 weeks in vaccines stolls anf by the pharyngeal route.
Pregnancy- use only if clearly needed. Use OPV in pregnancy if exposure is imminent and immediate protection is needed.
Lactation- breast feeding does not generally interfere with successful immuninization of infants , despite 1gA secretion in milk.
Children- administer 2, 4, and 15 or 18 months of age, and at 4 to 6 years of age. An addional dose at 6 months of age opitional.
Dosages/ Overdosage Etc:
Selective immunisation against polio
Dosage-
Primary immunizing series- three 0.5ml doses, optimally staring at 6 to 12 months of age. Give the second dose not < 6 and preferably 8 weeks later, commonly at 4 months of age.
Missed dose-
1. If you miss a dose of this medicine, and remember it on the day it should be taken, take it as directed.
2. However, if you do not remember the mised dose until the next day,take the missed dose at that time and reschedule your every-other-day doses from then.
3. It is important that this vaccine be taken exactly as directed so that it can give you protection against Polio
Other Information:
For Availability/supplies
Contact -
1.Indian Drug Manufacturers Association (IDMA)
Phone- 022- 24944624/ 24974308
Fax- 022- 24950723
Email- idma@vsnl.com
Website: www.idma-assn.org
2.Bulk Drug Manufacturers Association (India)(BDMA)
Phone - 040-23703910/ 23706718
Fax- 040-23704804
Email- info@bdmai.org
Website: www.info@bdmai.org
Patient Information:
Ref - USP PDI Vol II 17th Edition (1997)
POLIO VIRUS VACCINE- Systemic
1.Allergies-
Tell your doctor if you have ever had any unusual or allergic reaction to
polio virus vaccine or to neomycin, penicillin, polymixin B or streptomycin.
Also tell your healthcare care professional if you are allergic to any other
substances such as foods. preservatives or dyes.
2. Diet-
Make certain your doctor knows if you are on any special diet, such as
low sugar diet because the oral solution of polio vaccine may be given to
you on a sugar cube.
3.Pregnancy-
Although it is not recommended for all pregnant women, polio vaccine is
given to pregnant women at great risk of catching polio.
4. Breast-feeding-
Polio vaccine has not been reported to cause problems in nursing babies
5.Children-
Use is not recommended in infants up to 6 weeks of age. For children
6 weeks of age and older, polio vaccine is not expected to cause different
side effects than it does in adults.
6.Older adults-
Although,there is no specific information comparing use of podophyllum in the
elderly with use in other age groups, this medicine is not expected to cause
any different side effects than in younger adults.
7. Other medicines-
Tell your doctor if you are using any of the following -
Cancer medicines or
Corticosteroids or
Radiation therapy - may reduce the useful effect of the vaccine
8. Other medical problems-
Make sure you tell your doctor if you have any other medical problems
especially-
Diarrhea or
Virus infection or
Vomiting - the condition may reduce the useful effect of this vaccine
Fever or
llness or
Wekness - the symptoms of the condition may be confused with the
possible side effects of the vaccine
Immune deficiency condition - the condition may increase the chance
of side effects of the vaccine
Pharmacology/ Pharmacokinetics:
Pharmacology-
Attenuated live virus vaccine produces active immunity by stimulating natural infection without producing symptoms of the disease.
Pregnancy and lactation:
Pregnancy-
Use only if clearly needed. Use OPV in pregnancy if exposure is imminent and immediate protection is needed.
Lactation-
Breast feeding does not generally interfere with successful immuninization of infants , despite 1gA secretion in milk.
Children-
Administer 2, 4, and 15 or 18 months of age, and at 4 to 6 years of age. An addional dose at 6 months of age opitional.
Manufacturer Details