Coumarin anti-coagulants and hypoglycemic agents ( especially  sulphonylureas )
Methotrexate , certain anti-inflammatory agents, uricosuric agents, spironolactone and corticosteroids
Valproic acid, acetozolamide, highly protein bound drugs, urinary alkalinizers,
ACE  inhibitors, beta-blockers.
Antacids with enteric coated prepns.
Chronic heavy alcohol use

Pain
Dysmenorrheoa

Allergic or asthmatic reactions.
GI upset /bleeding
Prolonged bleeding time.
Salicylism
Reyes syndrome

Peptic ulcer, haemophilia or other bleeding disorders
Aspirin- amti-inflammatory induced allergies
Viral infection in childfren and teenagers
Lactation

Special precautions:
Gout
History of bronchspasm or asthma
Impaired renal or hepatic function
Dyspepsia, Elderly,Children
Diabetes
Pregnancy ( avoid at term )

Pain
Dysmenorrheoa

Dosage-
1 tabs 3-4 times daily
Maximum - 6 tabs per day

Not reported.

Contraindicated for use pregnancy and lactation.
Observe caution if use is required