MAOIs, tetracyclines, Phenytoin CNS depressants, narcotics, alcohol, Anticogulants, Probenecid. bisulphan, metrocloprapamide Colestyramine Smoking

Moderate to severe pain

Sedation, dizziness, Nausea, vomiting Psychotomimetics effects Dependence, sweating, tachycardia Hypertension, Local tissue damage Rash, haemotological changes Risk of hepatotoxicity among chronic heavy alcohol users Hepatotoxcity ( overdosage only) Sprorts events- Resricted/banned

Head injury or pathological brain condition Raised intracranial pressure. Narcotic dependence Acute bronchial asthma Respiratory depression Heart failure secondary to chronic lung disease Acute alcholism

Special precautions-

Thyroid, pitutiary disorders Previous narcotics MAOI . History of seizures, biliray surgery Acute MI . Inflammatory or bowel disorders. Prostatic hypertrophy. Porphyria.

Elderly. Renal , hepatic or respiratory impairment. Pregnancy, lactation. Phaeocromocytoma, cholescystis, pancreatitis Undiagnosed abdominal pain

Moderate to severe pain

Dosage-

1-2 tabs 3 times daily

Contraindicated for use during pregnancy and lactation Observe caution if required to be used