Tricylic Compounds include-
      Tertiary amines - Amitriptyline,Clomipramine,Doxepin,Imipramine,Trimipramine
      Secondary amines - Amoxipine, Desipramine, Nortriptyline,Portriptyline
      Refer - Amitriptyline

Drug interactions- summary

Imipramine +

MAOIs. - fatal reactions may occur in combination with MAOIs Adrenaline, noradrenaline and methylpenidate - Severe hypertension Guanithedine, betaanidine,debrisoquine and bretylin. - reverses hypotension effects

Methyldopa and clonidine. - interferes with hypertensive action

Anticonvulsants - Reduction in seizure thresold, anticonvulsant dose to be increased.

Levopdopa - Interferes with absorption of levadopa.

Tranquillisers - tranquillsers inhibit metabolism,

Oral contraceptives - Oral contraceptives reduce bioavailability,

Barbiturates - reduce plasma levels thereby reducing antidepressant effect.

Cimetidine - elevates serum impiramine concentrations and adverse effect

Alcohol - combination with alcohol causes drowsiness and impaired performance.

Imipramine with  MAOIs. fatal reactions may occur in combination with MAOIs  Adrenaline, noradrenaline and methylpenidate. Severe hypertension with Guanithedine, betaanidine,debrisoquine and bretylin. reverses hypotension effects Methyldopa and clonidine. interferes with hypertensive action

Anticonvulsants -Reduction in seizure thresold, anticonvulsant dose needs to be increased.

Levopdopa -Interferes with absorption of levadopa.

Tranquillisers -Major tranquillsers inhibit metabolism, Oral contraceptives Oral contraceptives reduce bioavailability,

Depression

      Tricylic Compounds include-
      Tertiary amines - Amitriptyline,Clomipramine,Doxepin,Imipramine,Trimipramine
      Secondary amines - Amoxipine, Desipramine, Nortriptyline,Portriptyline
      Refer - Amitriptyline

Rare agranulocytosis. Sinus tachycardia. A.V.bundle branch block, postural hypotension,

Dry mouth,constipation,urinary hesistency/retention,

Blurring of vision,exacerbation of glaucoma, Impotence,liver dydsfunction,

Weight gain,esoinophollia, leucopenia,fine tremors.

Post M.I. bundle branch block,epilepsy.

Special precautions: BHP,mania,safety in pregnancy not established. Gradual withdrawal.

Indications: Depression Dosage: 100 to 150mg in divided doses.

Children - 1.5mg/kg in 3 divided doses.

Tricyclic antidepressants include - Amitriptyline, Doxepin, Nortriptyline, Dothiepin, Amineptine, Imipramine, Clomipramine, Mianserin

Refer- Amitriptyline

AVOID CONCURRENT USE WITH ERYTHROMYCIN

Refer amitriptyline.

None reported.

Refer amitriptyline