PROTHIADEN
Brand:
PROTHIADEN
Manufacturer:
ABBOTT
Manufacturer Details
ABBOTT
ABBOTT HEALTHCARE PVT LTD
271 BUSINESS PARK 6TH FLOOR
MODEL INDUSTRIAL COLONY
GOREGAON EAST
MUMBAI 400063
Compositions:
Dothiepin Hydrochloride 25mg/50mg/75mg tablets,
|
Strength
|
Rate
|
Packing Style
|
|
25mg
|
100.50
|
10s tablets
|
|
50mg
|
197.91
|
10s tablets
|
|
75mg
|
209.46
|
10s tablets
|
List of Related Indications:
- Anxiety with depression
- Depression
List Of Drugs:
Indication Type Description:
Pharmacology/ Pharmacokinetics
Drug Interaction:
Tricyclic antidepressants include - Amitriptyline, Doxepin, Nortriptyline, Dothiepin, Amineptine, Imipramine, Clomipramine, Mianserin Refer- Amitriptyline
MAOIs potentiate action, hence should not be given concurrrently or within 14 days of stopping MAOIs. Potentiates catacholamines, sympathomemimetics, narcotics and alcohol. Reduces hypotensive activity of bethanidine, guanethedine. Barbiturates reduces antidepressant effect of Dothiepin. Raised serum concentration with methylphenidate. Cigarette smoking enhances metabolism.
Indication:
Depression
Tricyclic antidepressants include - Amitriptyline, Doxepin, Nortriptyline, Dothiepin, Amineptine, Imipramine, Clomipramine, Mianserin Refer- Amitriptyline
Adverse Reaction:
Bone marrow depression and agranulocytosis, Reports of ventricular fibrillation and renal failure. Cholestatic jaundice exacerbation of psychotic manifestation, Cardiac arrhythmias, hypotension, Dry mouth, disturbances of accomodation, Tachycardia, constipation, drowsiness, postural Hypotension, tremors and skin rash. Withdrawal symptoms with abrupt cessation,insomnia, Irritability and excessive sweating.
Contra-Indications:
Recent myocardial infarction,neonates,heart block,cardiac arrhythmias,maniac, Pregnancy.
Special precautions:
Epilepsy,hypertension,glaucoma,urinary retension,gradual withdrawal.
Dosages/ Overdosage Etc:
FDA provisional approval in 1993
Indications:
Depression
Dosage:
75 to 300mg a day.
Patient Information:
Tricyclic antidepressants include - Amitriptyline, Doxepin, Nortriptyline, Dothiepin, Amineptine, Imipramine, Clomipramine, Mianserin Refer- Amitriptyline
Pharmacology/ Pharmacokinetics:
Refer amitriptyline
Interaction with Food:
Not reported.
Pregnancy and lactation:
Contraindicated for use during pregnancy and lactation Observe caution if required to be used
