Brand Information

Strength	Rate	Packing Style
500mg	18.97	25s chewable tablets

Drug Interaction:

Interacting drugs- summary

Ascorbic acid +

Contraceptives, oral and oestrogens-

Ascorbic acid increases serum levels of oestrogens and

oestrogen containing contraseptives, resulting in

adverse reactions.

Warfarin-

anticoagulant action of warfarin reduced.

Indication:

Scurvy

Adverse Reaction:

Large doses may cause diarrhoea and precipitation of cystine oxalates or urate stones if the urine becomes acidic during therapy.

Transcient mild soreness may occur at the site of IM or SC injection.

Too rapid IV administration may cause temporary faintness or dizziness.

Contra-Indications:

None reported.

Special precautions:

Excessive vitamin C doses- diabetics, patients prone to renal calculli,those undergoing stool occult blood tests and those on sodium restricted diets or anticoagulant therapy should not take excessive doses of vitamin C over the extended period of time.

Pregnancy- not known whether ascorbic acid can cause fetal harm or can affect reproduction capacity.

Give to pregnant women only if needed. Do not administer to pregnant women in excess of the amount needed.

Lactation- administer with caution to nursing mother. Ascorbic acid is excreted in breast milk, but does not necessarily increase in response to increasing doses.

Dosages/ Overdosage Etc:

Indications: Scurvy

Dosage: Average dose 75 to 100 mg/day

Scurvy- 300 mg to 1 g daily

Other Information:

ANTIOXIDANTS AND METHYLATING AGENTS

Folic acid, pyridoxine, cyanocobalamin

Folic acid is esstential for cell replication and growth. It is required for the synthesis for DNA proteins, RBCs and for energy production

Pyridoxine (Vitamin B6) functions as a co-enzyme in synthesis of haeme, neurotransmitters and nucleic acid.

Cynanocobalamin (vitamin B-12) acts as a co-factor in the conversion of methylmalonyl-co A to succinyl-coA in homocysteine metabolism, the B-vitamin folate, B-12 and B-6 function as essential cofactors and coenzymes in regulating the remethylation and trans-sulfuration pathways. Studies show that a good number of the adult

population are deficient in these three vitamins.

Choline- Choline is required for the synthesis of phospholipids, phosphatidyl choline and spingomycetin -the structural components for all human cell membranes. Choline is a precursor for acetylcholine, an important neurotransmitter involved in muscle control, memory and many other functions.

Betaine, a derivative of choline is a source of methyl groups required for methylation reactions. Methyl groups from betaine may be used to convert homocysteine to methionine. The role of choline in methylation probably explains the finding that choline-deficient diets are associated with an increased rate of cancer in animal studies.

Choline have a beneficial role in neurodegenerative disorders.

Methionine- It is an essential amino acid and a principal supplier of sulfur, which prevents disorders of the hair, skin and nails.It also helps in lowering the cholesterol levels by increasing the hepatic production of lecithin. It also reduces hepatic

fat, protects the kidneys, regulates the formation of ammonia, influences hair follicles and promotes hair growth. It is a natural chelating agent for heavy metals.

Lycopene-It is a potent antioxidant carotenoid present in tomatoes. It s supplementation has been shown to be associated with a decreased risk of cardiac disease, cancer of the prostrate, breast, lung, colon, endometrium and cervix

Vitamin C- It is a water soluble antioxidant that scavenges superoxide, hydroxyl radicals and single oxygen. It protects against cancer cell growth by destroying free radicals, increasing collagen synthesis, altering DNA and protein metabolism

preventing transformation of precancerous cells to cancerous cells and producing cytotoxicity in cancer cells In epidemological studies.

Vitamin C has been shown to have a protective effect in preventing and treating oesophageal , oral pharyngeal, stomach, lung, cervical, rectal, colon, and pancreatic cancer. In addition,supplementation with the combination of Vitamin C and Vitamin E has shown to slow down artherosclerotic progression in hypercholesterolemic persons.

Vitamin E- It helps to prevent oxidation of ployunsaturatted fatty acids and fat soluble vitamins in the body and stimulates the immune system to destroy tumor cells as they are transformed to cancerous state. It has been shown to prevent cancer and cardiovascular disease. It also aids in normal blood clotting and healing. Vitamin E intake from food

or supplements is also associated with less congnitive decline with age and may have an important role in neurodegenerative disorders.

Selenium- Se;enium acts as an antioxidant by activating the enzyme glutathione peroxidase. People living in areas with selenium -poor soils are found to have higher cancer rates than those living in selenium-rich soils areas.

Red bush tea extract - Also known as Rooibos tea extract, it is caffeine free and has a low tannin content. It is highly defensive natural antioxidant including falvanoids. Because of its contents, it may be antiaging, particularly in preventing age-related byproduts of oxidaton of the brain. It was shown to inhibit the cancer causing- causing effect of X_Rays in test

animals. It has also been successfully used in the management of various dermatolgical conditions.

Containdications:

Hypersensitivity to any ingredients

Precautions:

Urine may give a false positive result by Benedicts test because of the presence of absorbic acid (Vitamin C)

Summary

Oxidative damage and antioxidant deficiency impacts on wide range of human diseases.

Several studies show that antioxidants like Vitamin C, Vitamin E, Selenium, carotenoids and methylating agents like the B-group Vitamins and choline have a beneficial effect in the prevention of chronic diseases.

Thus the combination of these nutrients may help prevent a host of diseases including cancer, cardiovascular disease and other chronic diseases.

Patient Information:

Ascorbic acid - Vitamin C - Systemic

1.Allergies-

Tell your doctor if you have ever had any unusual or allergic reaction to ascorbic acid

Also tell your healthcare provider if you are allergic to any other substances,

such as foods, sulfites, or other preservatives or dyes.

2.Pregnancy-

It is especially important that you are receiving enough vitamins when you become

pregnant and that you continue to receive the right amount of vitamins througout

your pregnancy. Healthy fetal growth and development depend on a steady supply

of nutrient from mother to fetus.

However, taking too much vitamin C daily throughout the pregnancy may harm

the fetus.

3. Breast-feeding-

It is especially important that you receive the right amounts of vitamins so that

your baby will also get the vitamins needed to grow properly. You should also check

with your doctor if you are giving your baby an unfortied formula. In that case, the

baby must get the vitamins needed some other way. However, taking large amounts

of a dietary supplement while breast-feeding may be harmful to the mother and /or

baby and should be avoided.

4.Children-

Problem in children have not been reported with intake of normal daily

recommended amounts.

5.Older adults-

Problems in older adults have not been reported with intake of normal daily

recommended amounts.

6.Other medicines-

Although certain medicines or dietary supplements should not be used together

at all, in other cases two different medicines may be used together even interaction

might occur. In such cases your doctor may want to change the dose , or other

precautions may be necessary.

Tell your doctor if you are using any other prescription or nonprescription

(over- the- counter OTC) medicine

7.Other medical problems-

The presence of other medical problems may affect the use of Vitamin C.

Make sure you tell your doctor if you have other any other medical problems,

especially-

Blood problems- high doses of vitamin C may cause certain blood problems

Diabetes mellitus- (sugar diabetes) - very high doses of vitamin C may, interfere

with tests for sugar in the urine

Glucose-6-phosphate-defeciency- (G6PD) - high doses of vitamin C may cause

hemolytic anemia

Kidney stones- (history of)- high doses of vitamin C may increase risk of

kidney stones in the utinary tract.

Interaction with Food:

Not significant

Pregnancy and lactation:

Pregnancy

not known whether ascorbic acid can cause fetal harm or can affect reproduction capacity. Give to pregnant women only if needed. Do not administer to pregnant women in excess of the amount needed.

Lactation

administer with caution to nursing mother. Ascorbic acid is excreted in breast milk, but does not necessarily increase in response to increasing doses.

CELIN

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Other Information

Patient Information

Interaction with Food

Pregnancy and lactation