CNS depressants   TCADs other antihypertensives

Alcohol

Sedatives and hypnotics

Dry mouth    headache     asthenia    dizziness   sleep disturbances

vertigo      g-i upset   vasodilation   sedation  back pain

rash   pruritus   anxiety

rarely skin reaction  angioedema 

Angioneurotic oedema  sick sinus syndrome
SA block   2nd and 3rd degree AV block

malignant arrhythmias  severe bradycardia < 50bpm
severe heart failure  coronary heart disease

hepatic or  severe  renal impairment
CrCl < 30ml/mm

Pegnancy  lactation elderly over 75 years

Special precautions-

moderate renal impairment CrCl 30-60ml/min
Reynonds disease  parkinsons disease,

epilepsy   glaucoma  depression
1st degree  AV block  unstable angina
moderate herat failure

withdraw gradually if stopping therapy after use with bdetablocker a few days before hand
intermittant claduication
galactose intolerence

Lapp tactase malabsorption

Indication-

Mild to moderate hypertension

Dosage-
initially 200mcg in the morning
increase if necessary after 2-3 weeks to 400mcg daily in divided doses

Elderly reduce dose

Renal impairment - maximum  200mcg per dose
 max daily 400mcg

Patients below 18 years not recommended

Use contraindicated.

Observe caution